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Clostridium difficile에 의한 설사의 예후인자

Other Titles
 Prognosis Factors of Clostridium difficile Associated Diarrhea 
Authors
 김준형  ;  김희정  ;  김준명  ;  이경원  ;  송영구  ;  최희경  ;  정수진  ;  김명수  ;  김연아  ;  박윤선  ;  신소연  ;  최준용  ;  김영근  ;  구남수 
Citation
 INFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.39(2) : 71-77, 2007 
Journal Title
 INFECTION AND CHEMOTHERAPY (감염과 화학요법) 
ISSN
 1598-8112 
Issue Date
2007
Abstract
Background:Clostridium difficile associated diarrhea (CDAD) has a wide range of clinical manifestations. The prognostic factors of CDAD are not fully understood. Materialsand Methods:A retrospective cohort study of 115 patients with CDAD from Aug. 2002 to Dec. 2003 was conducted to evaluate prognostic factors of CDAD. Bacteriologic factors were determined by detecting the binary toxin gene, tcd A, tcd A rep and tcd B gene. Poor prognosis was defined as diarrhea more than 10 days even with classic treatment, recurrence, death, and moribund discharge. Results:Approximately 79% of isolated strains were toxin A+/B+ strains and 21% were toxin A-/B+ strains. There was no difference in prognosis between toxin A+ and toxin A- strains. 39 (33.9%) cases showed poor prognosis and 76 (66.1%) cases showed good prognosis. Univariate analyses revealed that the poor prognostic factors were old age over 70 years old, male, the number of antibiotics used after onset of symptom, the administration of carbapenems, aminoglycosides, glycopeptides after onset of symptom, history of DM and stroke, and high Charlson comorbidity index. Multiple logistic regression analysis identified old age over 70 years old (odds ratio=3.378, P=0.009) and the administration of carbapenems after onset of symptom (odds ratio 7.210, P<0.001) as the independent poor prognostic factors. Conclusion:Old age over 70 and the administration of carbapenems after onset of symptom were the poor prognostic factors for CDAD caused by none-binary toxin producing strains.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Myoung Soo(김명수)
Kim, Yeon A(김연아)
Kim, Young Keun(김영근)
Kim, June Myung(김준명)
Kim, Joon Hyung(김준형)
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
Park, Yoon Seon(박윤선)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Shin, So Youn(신소연)
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97590
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