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Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms

Authors
 Da-Jung Chung  ;  Hye-Yeon Kim  ;  Joo Hyun Park  ;  Ju Youn Hwang  ;  Si Hyun Cho  ;  Cheong Mee Kim  ;  Sang Wook Bai  ;  Byung Seok Lee  ;  Min-Sun Cho  ;  Sung-Eun Hur  ;  Yu-Il Lee  ;  Sung-Ki Lee  ;  Kyung-Ah Jeong  ;  Ki-Hyun Park 
Citation
 YONSEI MEDICAL JOURNAL, Vol.48(2) : 289-294, 2007 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2007
Abstract
PURPOSE: This study was conducted to investigate the efficacy of black cohosh (Cimicifuga racemosa) and St. John's wort (Hypericum perforatum) in women with climacteric symptoms, and to assess their effects on vaginal atrophy, hormone levels, and lipid profiles.

MATERIALS AND METHODS: In this double-blind randomized, placebo-controlled, multicenter study, 89 peri- or postmenopausal women experiencing climacteric symptoms were treated with St. John's wort and black cohosh extract (Gynoplus), Jin-Yang Pharm., Seoul, Korea) or a matched placebo for 12 weeks. Climacteric complaints were evaluated by the Kupperman Index (KI) initially and at 4 and 12 weeks following treatment. Vaginal maturation indices, serum estradiol, FSH, LH, total cholesterol, HDL- cholesterol, LDL-cholesterol, and triglyceride levels were measured before and after treatment. From the initial 89 participants, 77 completed the trial (42 in the Gynoplus group, 35 in the placebo group).

RESULTS: Baseline characteristics were not significantly different between the two groups. Mean KI scores and hot flushes after 4 and 12 weeks were significantly lower in the Gynoplus group. Differences in superficial cell proportion were not statistically significant. HDL levels decreased in the control group from 60.20 +/- 16.37 to 56.63 +/- 12.67, and increased in the Gynoplus group from 58.32 +/- 11.64 to 59.74 +/- 10.54; this was statistically significant (p=0.04).

CONCLUSION: Black cohosh and St. John's wort combination was found to be effective in alleviating climacteric symptoms and might provide benefits to lipid metabolism
Files in This Item:
T200700516.pdf Download
DOI
10.3349/ymj.2007.48.2.289
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Cheong Mee(김청미)
Kim, Hye Yeon(김혜연)
Park, Ki Hyun(박기현)
Park, Joo Hyun(박주현)
Bai, Sang Wook(배상욱) ORCID logo https://orcid.org/0000-0001-7724-7552
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Chung, Da Jung(정다정)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Hwang, Ju Youn(황주연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97501
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