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The prevalence of human papillomavirus infection in Korean non-small cell lung cancer patients

Authors
 Moo Suk Park  ;  Yoon Soo Chang  ;  Se Kyu Kim  ;  Sung Kyu Kim  ;  Joon Chang  ;  Young Sam Kim  ;  Chang Hoon Hahn  ;  Shin Myung Kang  ;  Jin Wook Moon  ;  Dong Hwan Shin  ;  Kyung Young Chung  ;  Dae Joon Kim  ;  Ju Hye Shin 
Citation
 Yonsei Medical Journal, Vol.48(1) : 69-77, 2007 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2007
Abstract
Human papillomavirus (HPV) infection is a co-carcinogen of lung cancer and contributes to its pathogenesis. To evaluate the prevalence of HPV infection, polymerase chain reaction (PCR) was employed to detect HPV 16, 18, and 33 DNA in tumor tissues of 112 patients with non-small cell lung cancer (NSCLC) who underwent curative surgery from Jan. 1995 to Dec. 1998 at Severance Hospital, Seoul, Korea. The patients consisted of 90 men and 22 women. Nineteen patients were under 50 years old (17%), and 92 patients (82%) were smokers. Fifty-three patients had adenocarcinomas, while 59 patients had non-adenocarcinomas. Early stage (I and II) cancer was found in 64 patients (57.1%) and advanced stage (III and IV) found in 48 (42.9%). The prevalence of HPV 16, 18, and 33 were 12 (10.7%), 11 (9.8%), and 37 (33.0%), respectively. Smoking status, sex, and histologic type were not statistically different in the presence of HPV DNA. The presence of HPV 16 was more common in younger patients and HPV 18 was more common in advanced stage patients. This study showed that the prevalence rate of HPV 16 and 18 infections in NSCLC tissue was low, suggesting HPV 16 and 18 infections played a limited role in lung carcinogenesis of Koreans. However, the higher prevalence of HPV 33 infections in Korean lung cancer patients compared to other Asian and Western countries may be important and warrants further investigation.
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DOI
10.3349/ymj.2007.48.1.69
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
강신명(Kang, Shin Myung)
김대준(Kim, Dae Joon)
김성규(Kim, Sung Kyu)
김세규(Kim, Se Kyu)
김영삼(Kim, Young Sam) ORCID logo https://orcid.org/0000-0001-9656-8482
문진욱(Moon, Jin Wook)
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
신동환(Shin, Dong Hwan)
장윤수(Chang, Yoon Soo) ORCID logo https://orcid.org/0000-0003-3340-4223
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
정경영(Chung, Kyung Young)
한창훈(Hahn, Chang Hoon)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97463
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