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Significant Association of ApoB/ApoA-I Ratio with Arterial Stiffness in Treated Hypertensive Patients

Authors
 Jung-Sun Kim  ;  Sungha Park  ;  Namsik Chung  ;  Yangsoo Jang  ;  Donghoon Choi  ;  Young-Guk Ko  ;  Chan-Mi Park 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.4(3) : 376-381, 2007 
Journal Title
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE 
ISSN
 1738-2696 
Issue Date
2007
Abstract
Introduction: Recent studies have demonstrated that the ratio of apolipoproteins B and apolipoprotein A-I is a better predictor of cardiovascular disease than conventional parameters of dyslipidemia. The purpose of this study was to determine whether apolipoprotein B/apolipoprotein A-I ratio is related to arterial stiffness in a population of treated, hypertensive patients. Methods: The study group consisted of 657 treated hypertension patients. The pulse wave velocity was determined by measuring hfPWV and baPWV with a VP-1000 pulse wave unit. Results: The average age of the study population was 55.9±10.1 years of age (range, 30 to 78) with 398 (60.7%) being male. The average ApoB level was 79.9±21.2 mg/dL and the average ApoAI level was 138.7±24.0 mg/dL. The average ApoB/ApoAI ratio was 0.60±0.19. The ApoB/ApoAI ratio was significantly lower in males due to the lower level of ApoAI. After controlling for age, gender, systolic blood pressure, heart rate, DM, body mass index (BMI), statins and smoking, ApoB/ApoAI was significantly associated with both hfPWV (R2 = 0.505, β = 0.068, P = 0.020) and baPWV (R2 = 0.480, β = 0.074, P = 0.013). Subgroup analysis revealed that the significant association of ApoB/ApoAI was significant only for the male population. [hfPWV (R2 = 0.562, β = 0.108, P = 0.003) and baPWV (R2 = 0.467, β = 0.104, P = 0.008)]. Conclusion: We demonstrated, for the first time, a significant association of ApoB/ApoAI with baPWV and hfPWV in treated, male hypertension patients, after adjustment for confounding factors and medications.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97405
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