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Significant Association of ApoB/ApoA-I Ratio with Arterial Stiffness in Treated Hypertensive Patients
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 최동훈 | - |
dc.date.accessioned | 2014-12-21T17:20:27Z | - |
dc.date.available | 2014-12-21T17:20:27Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97405 | - |
dc.description.abstract | Introduction: Recent studies have demonstrated that the ratio of apolipoproteins B and apolipoprotein A-I is a better predictor of cardiovascular disease than conventional parameters of dyslipidemia. The purpose of this study was to determine whether apolipoprotein B/apolipoprotein A-I ratio is related to arterial stiffness in a population of treated, hypertensive patients. Methods: The study group consisted of 657 treated hypertension patients. The pulse wave velocity was determined by measuring hfPWV and baPWV with a VP-1000 pulse wave unit. Results: The average age of the study population was 55.9±10.1 years of age (range, 30 to 78) with 398 (60.7%) being male. The average ApoB level was 79.9±21.2 mg/dL and the average ApoAI level was 138.7±24.0 mg/dL. The average ApoB/ApoAI ratio was 0.60±0.19. The ApoB/ApoAI ratio was significantly lower in males due to the lower level of ApoAI. After controlling for age, gender, systolic blood pressure, heart rate, DM, body mass index (BMI), statins and smoking, ApoB/ApoAI was significantly associated with both hfPWV (R2 = 0.505, β = 0.068, P = 0.020) and baPWV (R2 = 0.480, β = 0.074, P = 0.013). Subgroup analysis revealed that the significant association of ApoB/ApoAI was significant only for the male population. [hfPWV (R2 = 0.562, β = 0.108, P = 0.003) and baPWV (R2 = 0.467, β = 0.104, P = 0.008)]. Conclusion: We demonstrated, for the first time, a significant association of ApoB/ApoAI with baPWV and hfPWV in treated, male hypertension patients, after adjustment for confounding factors and medications. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 376~381 | - |
dc.relation.isPartOf | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Significant Association of ApoB/ApoA-I Ratio with Arterial Stiffness in Treated Hypertensive Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Namsik Chung | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Chan-Mi Park | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03585 | - |
dc.contributor.localId | A04053 | - |
dc.relation.journalcode | J02734 | - |
dc.identifier.eissn | 2212-5469 | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 4 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 376 | - |
dc.citation.endPage | 381 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.4(3) : 376-381, 2007 | - |
dc.identifier.rimsid | 50492 | - |
dc.type.rims | ART | - |
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