4 482

Cited 3 times in

Antidepressant effect of stem cell-derived monoaminergic grafts

Authors
 Miles G. Cunningham  ;  Rachael A. Donalds  ;  Kwang-Soo Kim  ;  Dong-Wook Kim  ;  Dae-Sung Kim  ;  Sunghoi Hong  ;  William A. Carlezon Jr 
Citation
 NEUROREPORT, Vol.18(16) : 1663-1667, 2007 
Journal Title
NEUROREPORT
ISSN
 0959-4965 
Issue Date
2007
Abstract
In this study, we demonstrate that embryonic stem cells can be engineered to differentiate into high percentages of serotonergic and dopaminergic neurons. In vitro, these cells release serotonin and dopamine in response to membrane depolarization. Upon engraftment into the medial prefrontal cortex in rats, the homolog of the human anterior cingulate cortex, the cells assumed neuronal morphologies, expressed monoaminergic-specific proteins, and seemed to functionally integrate, as assessed by the upregulation of the immediate-early gene, cfos. Furthermore, the transplanted animals performed in a manner similar to that of animals that received the antidepressant, citalopram, when administered the forced swim test, a validated model of human depression. These results suggest that transplantation of customized stem cells might perhaps be useful in the study treatment of psychiatric disorders.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200710290-00006&LSLINK=80&D=ovft
DOI
10.1097/WNR.0b013e3282f0eb1c
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0002-5025-1532
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97196
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links