Cited 3 times in
Antidepressant effect of stem cell-derived monoaminergic grafts
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동욱 | - |
dc.date.accessioned | 2014-12-21T17:13:56Z | - |
dc.date.available | 2014-12-21T17:13:56Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97196 | - |
dc.description.abstract | In this study, we demonstrate that embryonic stem cells can be engineered to differentiate into high percentages of serotonergic and dopaminergic neurons. In vitro, these cells release serotonin and dopamine in response to membrane depolarization. Upon engraftment into the medial prefrontal cortex in rats, the homolog of the human anterior cingulate cortex, the cells assumed neuronal morphologies, expressed monoaminergic-specific proteins, and seemed to functionally integrate, as assessed by the upregulation of the immediate-early gene, cfos. Furthermore, the transplanted animals performed in a manner similar to that of animals that received the antidepressant, citalopram, when administered the forced swim test, a validated model of human depression. These results suggest that transplantation of customized stem cells might perhaps be useful in the study treatment of psychiatric disorders. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1663~1667 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Antidepressant effect of stem cell-derived monoaminergic grafts | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Miles G. Cunningham | - |
dc.contributor.googleauthor | Rachael A. Donalds | - |
dc.contributor.googleauthor | Kwang-Soo Kim | - |
dc.contributor.googleauthor | Dong-Wook Kim | - |
dc.contributor.googleauthor | Dae-Sung Kim | - |
dc.contributor.googleauthor | Sunghoi Hong | - |
dc.contributor.googleauthor | William A. Carlezon Jr | - |
dc.identifier.doi | 10.1097/WNR.0b013e3282f0eb1c | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00406 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200710290-00006&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Kim, Dong Wook | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 1663 | - |
dc.citation.endPage | 1667 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.18(16) : 1663-1667, 2007 | - |
dc.identifier.rimsid | 55238 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.