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한국인의 혈청 아디포넥틴과 당뇨병 진단기준 실정에 관한 연구

Other Titles
 The Association Between Adiponectin and Diabetes in the Korean Population 
Authors
 지선하  ;  이희연  ;  김현숙  ;  박정용  ;  김상연  ;  송혜윤  ;  지은정  ;  윤지은  ;  이선주 
Citation
 Korean Journal of Epidemiology (한국역학회지), Vol.29(2) : 176-186, 2007 
Journal Title
 Korean Journal of Epidemiology (한국역학회지) 
ISSN
 1225-3596 
Issue Date
2007
Abstract
Background: As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well known risk factor for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population. Methods: The WC, BMI, and serum adiponectin were measured in 6,505 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126㎎/dL or taking medication. Results: Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high density lipoprotein cholesterol (HDL) cholesterol (P<0.001). After adjusting for age, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in both men and women. The best cut-off value of adiponectin in terms of identifying the presence of diabetes was 5.5㎍/㎖ with a sensitivity and specificity of 46.7% and 63.9% for men and 9.5㎍/㎖ with a sensitivity and specificity of 68.2% and 55.2 for women. Conclusions: These results suggest that adiponectin was associated with diabetes. The association was independent of WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC on diabetes.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96897
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