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혈청 아디포넥틴 측정 키트(AdipoMark)의 개발과 심혈관질환 위험요인과의 관련성 연구

Other Titles
 Development of ELISA-kit of Quantitative Analysis for Adiponectin and Their Correlation with Cardiovascular Risk Factors 
Authors
 지선하  ;  이승복  ;  송혜윤  ;  이희연  ;  지은정  ;  이선주  ;  윤지은  ;  김상연  ;  김현숙  ;  박정용  ;  민성식 
Citation
 Korean Journal of Epidemiology (한국역학회지), Vol.29(2) : 165-175, 2007 
Journal Title
 Korean Journal of Epidemiology (한국역학회지) 
ISSN
 1225-3596 
Issue Date
2007
Abstract
Purposes: To develop a rapid, sensitive, qualitative ELISA-kit for serum adiponectin and examine correlation with adiponectin and cardiovascular risk factors.Methods: On the base of monoclonal antibodies against adiponectin, apply indirect ELISA to study the performance parameter of the kit. The correlation was examined between adiponectin and cardiovascular risk factors including waist circumference, body mass index, triglyceride, and HDL cholesterol.Results: The limited concentration of detection of the ELISA-kit was 1㎍/㎖. Linearity with R&D system and AdipoGen with this ELISA-kit was acceptable: the linear equation with R&D system was y=1.0116x+0.4629 (R2=0.97) and linear equation with AdipoGen was y=0.9562x+1.1961 (R2=0.93), respectively. The average recovery rate of the ELISA-kit ranged 92 to 104%. The correlation coefficient of waist circumference with adiponectin was -0.2276 (p<0.0001) among men and -0.2328 (p<0.0001) among women.Conclusion: This ELISA-kit was quick, sensitive, and stable and can be used to determine adiponectin in serum.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96895
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