Solitary dermatofibroma shows a common occurrence, especially on the lower limbs of young women, while multiple eruptive dermatofibromas are rare and are thought to be associated with altered immunity, such as autoimmune diseases and immunosuppression. We report a patient with systemic lupus erythematosus (SLE) and juvenile rheumatoid arthritis (JRA) who developed multiple, eruptive dermatofibromas while she was being treated with systemic corticosteroid. We also review literature on the previously reported cases of multiple eruptive dermatofibromas associated with SLE.