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HLA항체 양성 환자에서 신장이식 전 혈장교환술의 항체 음성 전환 효과

Other Titles
 The Efficiency of Plasma Exchange for Renal Allograft Recipients with HLA Antibody before Transplantation 
Authors
 이성실  ;  김순일  ;  김현옥  ;  이경애  ;  박윤희  ;  김창기 
Citation
 Korean Journal of Blood Transfusion (대한수혈학회지), Vol.18(1) : 1-8, 2007 
Journal Title
 Korean Journal of Blood Transfusion (대한수혈학회지) 
ISSN
 1226-9336 
Issue Date
2007
Abstract
Background: Therapeutic plasma exchange (TPE) is used to remove antibodies from the blood stream, thereby preventing them from attacking their targets. We evaluated the strategies to increase the efficiency of TPE for renal allograft recipients with HLA antibody. Methods: A total of 11 patients were evaluated from January 2002 to April 2004. All the patients had been diagnosed with end stage renal disease (ESRD) and then they were scheduled for renal transplantation from a living unrelated donor or a living related donor. TPE was performed for all lymphocyte cross-matching (LCM) positive recipients before renal transplantation. One to three sessions of TPE were performed in 8 patients and four to seven sessions of TPE were performed in 3 patients (mean: 2.81 times). We used normal saline and 4% albumin as a replacement solution. Results: Eleven patients, after the patients' LCM positive serum converted to negative, received the renal transplantation. Of the 11 recipients, only 1 recipient suffered from chronic rejection. Ten recipients maintained normal renal function. Among the 11 recipients, 4 recipients were diagnosed with posttransplantation diabetes mellitus. 3 recipients had a past history of graft failure via acute or chronic rejection. Even these 3 recipients experienced successful renal allograft through pre-transplantation TPE. Also, all the recipients were followed up until June, 2005. Conclusion: For ESRD patients with positive LCM, pre-transplantation TPE dramatically decreases the incidence of acute or chronic rejections by converting positive LCM into negative LCM.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Chang Ki(김창기)
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96847
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