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흰쥐의 포르말린 검사에서 척수강내로 혼합 투여한 NMDA 수용체 길항제와 5-HT3 수용체 작동제의 상호 작용

Other Titles
 The Interaction between Intrathecal NMDA Receptor Antagonist and 5-HT3 Receptor Agonist in the Rat Formalin Test 
 한동우  ;  권태동  ;  김선종  ;  이윤우  ;  유영철  ;  이종석 
 Korean Journal of Anesthesiology (대한마취과학회지), Vol.52(6) : 694-701, 2007 
Journal Title
 Korean Journal of Anesthesiology  (대한마취과학회지) 
Issue Date
Background A single agent administered is not effective enough to block nociception. Combination of agents acting through different mechanisms may be one of the best ways for better analgesic methods. The purpose of this study was to investigate the spinally mediated analgesic interaction between 5-HT3 receptor agonist (m-CPBG) and NMDA receptor antagonist (MK801) in the rat formalin test. Methods A polyethylene catheter was inserted in the atlanto-occipital membrane to the thoracolumbar level of the spinal cord. On postoperative 7 day, the normal saline (n = 6), m-CPBG (10, 30, 100µg: n = 18) and MK801 (0.1, 1, 10µg: n = 18) were injected intrathecally before subcutaneous injection of 5% formalin. The combinations of each 1/2ED50 + 1/2ED50, 1/4ED50 + 1/4ED50, 1/8ED50 + 1/8ED50 were tested and the ED50 of the combination was determined. The experimental ED50 values were compared with the theoretical additive values. Results m-CPBG dose-dependently decreased the number of flinches in both phase 1 and 2. MK801 dose-dependently reduced the number of flinches in phase 2, but not in phase 1. The combination of m-CPBG and MK801 produced dose-dependent decreases of flinches on both phase 1 and 2. ED50 values (2.75µg for m-CPBG and 0.076µg for MK801) of phase 2 in the combination were significantly less than the calculated additive values (20.0µg for m-CPBG and 0.55µg for MK801)(P < 0.01). Conclusions Intrathecally administered m-CPBG and MK801 had synergistic analgesic effects on formalin-induced hyperalgesia as well as antinociceptive effects in phase 1 on the rat formalin test.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
권태동(Kweon, Tae Dong) ORCID logo https://orcid.org/0000-0002-5451-1856
이윤우(Lee, Youn Woo)
이종석(Lee, Jong Seok) ORCID logo https://orcid.org/0000-0002-7945-2530
한동우(Han, Dong Woo) ORCID logo https://orcid.org/0000-0002-8757-663X
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