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Effect of (1→3)(1→6)-B-Glucan containing PLGA Scaffold on human dermal fibroblast attachment and prolferation

Authors
 Sang Gil Lee  ;  Jung Bok Lee  ;  Jeong Koo Kim  ;  Young Il Yang  ;  Jong Chul Park 
Citation
 Key Engineering Materials, Vol.342~343 : 377-380, 2007 
Journal Title
 Key Engineering Materials 
ISSN
 1013-9826 
Issue Date
2007
Abstract
The effect of β-glucan-reinforced PLGA scaffold on cell proliferation was investigated. The PLGA scaffolds were prepared by salt-leaching method. The prepared scaffolds were grafted with (1→3) (1→6)-β-glucan in various ratios after plasma treatment on the surface. The surface of the scaffold was characterized by scanning electron microscope (SEM). The HDFs (Human dermal fibroblasts, 1 105 cells/scaffold) were used to evaluate the cell proliferation on PLGA scaffold before and after plasma/β-glucan treatment. In results, in the β-glucan treated scaffolds, the pores seemed to become narrower and even looked like closed form. The result of cell proliferation showed that the plasma/β-glucan treated scaffolds had narrower pores because the β-glucan was attached in the pores that would not be allowed the cells to penetrate into the inner areas. Consequently, cell proliferation was not effective in the plasma/β-glucan treated scaffolds in this study.
Full Text
http://www.scientific.net/KEM.342-343.377
DOI
10.4028/www.scientific.net/KEM.342-343.377
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Jung Bok(이정복)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96774
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