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Vascular Smooth Muscle Cell Behaviors onto Epigallocatechin- 3-O-Gallate-Blended L-Lactide/ε-Caprolactone Copolymers

Authors
 Dong Wook Han  ;  Han Hee Cho  ;  Suong Hyu Hyon  ;  Jong Chul Park  ;  Kazuaki Matsumura  ;  J.J. Lee  ;  Duk Young Jung 
Citation
 Key Engineering Materials, Vol.342~343 : 189-192, 2007 
Journal Title
 Key Engineering Materials 
ISSN
 1013-9826 
Issue Date
2007
Abstract
In this study, such behaviors of vascular smooth muscle cells (VSMCs), as proliferation and migration, with serum stimulation were investigated onto (−)-epigallocatechin-3-O-gallate (EGCG)-blended poly(L-lactide-co-ε-caprolactone, PLCL) copolymers (EGCG-b PLCL). VSMCs were primarily cultured from rat aorta, and EGCG-b PLCL films were fabricated by mixing PLCL with EGCG. The proliferation of VSMCs cultured onto EGCG-b PLCL film was significantly suppressed in spite of serum induction. Moreover, recovery of denuded area by VSMCs receiving conditioned media obtained from EGCG-b films was completely inhibited, whereas VSMCs onto intact films migrated into denuded area in response to serum showing essentially complete recovery. These results suggest that inhibition in the behaviors of serum-stimulated VSMCs may be mediated through the anti-proliferative effects of EGCG released from polymer films, and EGCG-b polymers can be applied for fabricating an EGCG-eluting vascular stent.
Full Text
http://www.scientific.net/KEM.342-343.189
DOI
10.4028/www.scientific.net/KEM.342-343.189
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Cho, Han Hee(조한희)
Han, Dong Wook(한동욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96769
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