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Regeneration of Bone Defect Using Micro-Bioceramic PLLA Polymer Scaffolds Synthesized by Nonsolvent and Solvent Method

Authors
 Min Sung Park  ;  Young Mee Jung  ;  Jin Woo Lee  ;  Byoung Goo Min  ;  Young Ha Kim  ;  Sang Heon Kim  ;  Soo Hyun Kim 
Citation
 Key Engineering Materials, Vol.342~343 : 145-148, 2007 
Journal Title
 Key Engineering Materials 
ISSN
 1013-9826 
Issue Date
2007
Abstract
Poly-L-lactic acid (PLLA) is a desirable and very attractive polymer for fabricating porous scaffolds. As of now, a solvent casting method with organic solvents has been used in scaffold fabrication process. However, residual organic solvents in the scaffolds have the problems of decreasing the effect of osteogenic induction due to the hindrance of bioceramic by polymer solution and it’s harmfulness in vivo. To avoid these disadvantages of scaffolds by organic solvent casting method, we developed a new method fabricating polymer (PLLA)/ceramic (β -TCP) composite scaffolds by baking method without using solvent, and then we tested properties of scaffolds on animals. As the result, non-toxicity has been proved through animal experiment and newly fabricated polymer/ceramic composites by a novel sintering method were induced rapid bone regeneration through enhancing the interaction of cells and a bone induction factor without any host immune response.
Full Text
http://www.scientific.net/KEM.342-343.145
DOI
10.4028/www.scientific.net/KEM.342-343.145
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96768
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