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Enhanced Stretch-Induced Myogenic Tone in the Basilar Artery of Spontaneously Hypertensive Rats

Authors
 Duck-Sun Ahn  ;  Soo-Kyoung Choi  ;  Young-Ho Lee  ;  Kathleen G. Morgan  ;  Heung Mook Shin  ;  Young-Eun Cho  ;  Young-Hwan Kim 
Citation
 JOURNAL OF VASCULAR RESEARCH, Vol.44(3) : 182-191, 2007 
Journal Title
JOURNAL OF VASCULAR RESEARCH
ISSN
 1018-1172 
Issue Date
2007
MeSH
Amides/pharmacology ; Animals ; Baroreflex* ; Basilar Artery/drug effects ; Basilar Artery/metabolism ; Basilar Artery/physiopathology* ; Calcium/metabolism ; Disease Models, Animal ; Hypertension/metabolism ; Hypertension/physiopathology* ; Intracellular Signaling Peptides and Proteins/metabolism ; Mechanotransduction, Cellular*/drug effects ; Pressoreceptors/metabolism ; Pressoreceptors/physiopathology* ; Protein Kinase C-alpha/metabolism ; Protein Kinase C-epsilon/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/metabolism ; Pyridines/pharmacology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Vasoconstriction*/drug effects ; rho-Associated Kinases ; rhoA GTP-Binding Protein/metabolism
Abstract
We investigated if the magnitude of myogenic tone in the basilar artery of SHR differs from that in WKY and, if so, whether RhoA- or PKC-dependent mechanisms were involved. Myogenic tone was developed in response to stretch. Stretch-induced myogenic contraction was significantly greater in the SHR than WKY in the presence of external Ca2+. However, in the absence of external Ca2+, stretch did not evoke a myogenic tone. The [Ca2+]i-induced contraction was larger in SHR than WKY and the [Ca2+]i-force curve was significantly shifted to the left in SHR compared to WKY. Y-27632 significantly inhibited stretch-induced myogenic tone, but the inhibitory effect was larger in the SHR than WKY. However, PKC inhibitors had no significant effect on the myogenic tone. RhoA and PKCε were expressed at higher levels in the SHR compared to the WKY. RhoA and PKCα translocated from the cytosol to the cell membrane in response to stretch in both animals, but PKCε was translocated only in SHR. Our results strongly suggest that stretch-induced myogenic tone is enhanced in SHR, and the activation of RhoA/Rho kinase plays an important role in the enhanced myogenic tone in SHR.
Full Text
http://www.karger.com/Article/FullText/100374
DOI
10.1159/000100374
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Hwan(김영환)
Ahn, Duk Sun(안덕선) ORCID logo https://orcid.org/0000-0001-9351-6951
Lee, Young Ho(이영호) ORCID logo https://orcid.org/0000-0002-5749-1045
Cho, Young Eun(조영은)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96723
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