Cited 19 times in
Enhanced Stretch-Induced Myogenic Tone in the Basilar Artery of Spontaneously Hypertensive Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영환 | - |
dc.contributor.author | 안덕선 | - |
dc.contributor.author | 이영호 | - |
dc.contributor.author | 조영은 | - |
dc.date.accessioned | 2014-12-21T16:59:07Z | - |
dc.date.available | 2014-12-21T16:59:07Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1018-1172 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96723 | - |
dc.description.abstract | We investigated if the magnitude of myogenic tone in the basilar artery of SHR differs from that in WKY and, if so, whether RhoA- or PKC-dependent mechanisms were involved. Myogenic tone was developed in response to stretch. Stretch-induced myogenic contraction was significantly greater in the SHR than WKY in the presence of external Ca2+. However, in the absence of external Ca2+, stretch did not evoke a myogenic tone. The [Ca2+]i-induced contraction was larger in SHR than WKY and the [Ca2+]i-force curve was significantly shifted to the left in SHR compared to WKY. Y-27632 significantly inhibited stretch-induced myogenic tone, but the inhibitory effect was larger in the SHR than WKY. However, PKC inhibitors had no significant effect on the myogenic tone. RhoA and PKCε were expressed at higher levels in the SHR compared to the WKY. RhoA and PKCα translocated from the cytosol to the cell membrane in response to stretch in both animals, but PKCε was translocated only in SHR. Our results strongly suggest that stretch-induced myogenic tone is enhanced in SHR, and the activation of RhoA/Rho kinase plays an important role in the enhanced myogenic tone in SHR. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 182~191 | - |
dc.relation.isPartOf | JOURNAL OF VASCULAR RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amides/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Baroreflex* | - |
dc.subject.MESH | Basilar Artery/drug effects | - |
dc.subject.MESH | Basilar Artery/metabolism | - |
dc.subject.MESH | Basilar Artery/physiopathology* | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Hypertension/metabolism | - |
dc.subject.MESH | Hypertension/physiopathology* | - |
dc.subject.MESH | Intracellular Signaling Peptides and Proteins/metabolism | - |
dc.subject.MESH | Mechanotransduction, Cellular*/drug effects | - |
dc.subject.MESH | Pressoreceptors/metabolism | - |
dc.subject.MESH | Pressoreceptors/physiopathology* | - |
dc.subject.MESH | Protein Kinase C-alpha/metabolism | - |
dc.subject.MESH | Protein Kinase C-epsilon/metabolism | - |
dc.subject.MESH | Protein Kinase Inhibitors/pharmacology | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/metabolism | - |
dc.subject.MESH | Pyridines/pharmacology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Inbred SHR | - |
dc.subject.MESH | Rats, Inbred WKY | - |
dc.subject.MESH | Vasoconstriction*/drug effects | - |
dc.subject.MESH | rho-Associated Kinases | - |
dc.subject.MESH | rhoA GTP-Binding Protein/metabolism | - |
dc.title | Enhanced Stretch-Induced Myogenic Tone in the Basilar Artery of Spontaneously Hypertensive Rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Duck-Sun Ahn | - |
dc.contributor.googleauthor | Soo-Kyoung Choi | - |
dc.contributor.googleauthor | Young-Ho Lee | - |
dc.contributor.googleauthor | Kathleen G. Morgan | - |
dc.contributor.googleauthor | Heung Mook Shin | - |
dc.contributor.googleauthor | Young-Eun Cho | - |
dc.contributor.googleauthor | Young-Hwan Kim | - |
dc.identifier.doi | 10.1159/000100374 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00732 | - |
dc.contributor.localId | A02223 | - |
dc.contributor.localId | A02968 | - |
dc.contributor.localId | A03856 | - |
dc.relation.journalcode | J01923 | - |
dc.identifier.eissn | 1423-0135 | - |
dc.identifier.pmid | 17337904 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/100374 | - |
dc.contributor.alternativeName | Kim, Young Hwan | - |
dc.contributor.alternativeName | Ahn, Duk Sun | - |
dc.contributor.alternativeName | Lee, Young Ho | - |
dc.contributor.alternativeName | Cho, Young Eun | - |
dc.contributor.affiliatedAuthor | Kim, Young Hwan | - |
dc.contributor.affiliatedAuthor | Ahn, Duk Sun | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Cho, Young Eun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 182 | - |
dc.citation.endPage | 191 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VASCULAR RESEARCH, Vol.44(3) : 182-191, 2007 | - |
dc.identifier.rimsid | 36430 | - |
dc.type.rims | ART | - |
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