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헌팅톤 병 동물 모델에서 치료효과 판정을 위한 운동기능 평가
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.contributor.author | 김현옥 | - |
dc.contributor.author | 박은숙 | - |
dc.contributor.author | 박창일 | - |
dc.contributor.author | 조성래 | - |
dc.date.accessioned | 2014-12-21T16:53:54Z | - |
dc.date.available | 2014-12-21T16:53:54Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1225-584X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96559 | - |
dc.description.abstract | Objective: To investigate which outcome measurements are useful for detecting functional changes after therapeutic approach to delayed motor impairment in an animal model of Huntington's disease (HD). Method: R6/2 transgenic mice received intraventricular injections of adenoviral BDNF/noggin (AdB/N), AdBDNF, AdNull (n=15 each) at 4 weeks of age. Untreated R6/2s and wild-type mice were also recruited as controls. Motor performance was measured using rotarod analysis and locomotor activity test at regular intervals until preterminal age of 13 weeks. Results: On constant speed rotarod testing, AdB/N-treated R6/2s exhibited a delayed disease progression after post operative 6 weeks. AdB/N also ameliorated general locomotor activity deficits. One min-rotarod analysis showed a delayed motor impairment in AdBDNF group at preterminal age compared with AdNull and untreated controls, which was not shown in 3 min and 5 min-rotarod. Accelerating rotarod paradigm was not superior to constant speed. Partial therapeutic effects on locomotor activities were detected in total 60 min-monitoring, but not in 30 min- or 10 minmonitoring. Conclusion: Appropriate behavioral testing and outcome measurements should be selected to detect the treatment effect to slow functional deterioration in HD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 503~511 | - |
dc.relation.isPartOf | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 헌팅톤 병 동물 모델에서 치료효과 판정을 위한 운동기능 평가 | - |
dc.title.alternative | Behavioral Testing for Therapeutic Outcome Measurements in an Animal Model of Huntington's Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | 조성래 | - |
dc.contributor.googleauthor | 박은숙 | - |
dc.contributor.googleauthor | 박창일 | - |
dc.contributor.googleauthor | 김동구 | - |
dc.contributor.googleauthor | 김현옥 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00396 | - |
dc.contributor.localId | A01122 | - |
dc.contributor.localId | A01611 | - |
dc.contributor.localId | A01717 | - |
dc.contributor.localId | A03831 | - |
dc.relation.journalcode | J01803 | - |
dc.subject.keyword | Huntington's disease | - |
dc.subject.keyword | Rotarod testing | - |
dc.subject.keyword | Locomotor activity | - |
dc.subject.keyword | Outcome measurement | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.alternativeName | Kim, Hyun Ok | - |
dc.contributor.alternativeName | Park, Eun Sook | - |
dc.contributor.alternativeName | Park, Chang Il | - |
dc.contributor.alternativeName | Cho, Sung Rae | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ok | - |
dc.contributor.affiliatedAuthor | Park, Eun Sook | - |
dc.contributor.affiliatedAuthor | Park, Chang Il | - |
dc.contributor.affiliatedAuthor | Cho, Sung Rae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 31 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 503 | - |
dc.citation.endPage | 511 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Academy of Rehabilitation Medicine (대한재활의학회지), Vol.31(5) : 503-511, 2007 | - |
dc.identifier.rimsid | 36167 | - |
dc.type.rims | ART | - |
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