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Prognostic Significance of Perinodal Extension in Gastric Cancer

 Won Hyuk Choi  ;  Sungsoo Kim  ;  Chan Il Park  ;  Sung Hoon Noh  ;  Seung Ho Choi  ;  Yong Il Kim  ;  Woo Jin Hyung  ;  Jae Ho Cheong  ;  Jiayun Shen 
 JOURNAL OF SURGICAL ONCOLOGY, Vol.95(7) : 540-545, 2007 
Journal Title
Issue Date
Adenocarcinoma/mortality ; Adenocarcinoma/secondary ; Adenocarcinoma/surgery* ; Adult ; Aged ; Aged, 80 and over ; Female ; Gastrectomy*/methods ; Humans ; Lymph Node Excision/mortality* ; Lymph Nodes/pathology* ; Lymphatic Metastasis ; Male ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Survival Rate
BACKGROUND: The grouping of patients who have a poor prognosis is important in determining a treatment strategy. The aim of this study was to investigate the clinicopathologic features and prognosis in patients with perinodal extension, with a focus on the difference of survival between homogenous groups. METHODS: This study included a total of 1,092 patients who underwent curative gastrectomy for gastric adenocarcinoma from 1997 to 2004 at the Department of Surgery, Yongdong Severance Hospital, Yonsei University College of Medicine. RESULTS: One hundred sixty-one patients had perinodal extension. The incidence of perinodal extension was positively correlated for T and N stages. Perinodal extension was identified as an independent prognostic factor and had more influence on survival than T and N stages. Patients who had nodal metastasis without serosal exposure and who had serosal exposure without nodal metastasis were selected as homogenous groups, and there was no difference of survival between these groups. However, when the nodal metastasis group was subdivided according to the perinodal extension, perinodal extension subgroup had significant poorer prognosis than no perinodal extension subgroup. CONCLUSIONS: The perinodal extension was the most important independent prognostic factor in gastric cancer, and should be included in the TNM gastric cancer staging system.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Park, Chan Il(박찬일)
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0002-9872-3594
Choi, Won Hyuk(최원혁)
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
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