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은행잎 추출물(EGb 761)에 의한 IL -1β 유도 MUC5AC 유전자 발현의 억제

Other Titles
 Suppression of IL-1β-induced MUG5AC Gene Expression by Ginkgo biloba Extract(EGb 761) in Human Airway Epithelial Cells 
Authors
 장정현  ;  김정홍  ;  김경수  ;  전주현  ;  조창일  ;  이근완 
Citation
 Journal of Rhinology, Vol.14(1) : 49-55, 2007 
Journal Title
Journal of Rhinology
ISSN
 1229-1498 
Issue Date
2007
Keywords
Ginkgo biloba extract 761 ; Interleukin-1β ; Mucins ; Epithelial cells
Abstract
Background and Objectives:The purpose of this study is to investigate whether Ginkgo biloba extract (EGb 761) can suppress IL-1β-induced MUC5AC gene expression in NCI-H292 human airway epithelial cells and to discover what its possible mechanism is. Materials and Methods:NCI-H292 human pulmonary mucoepidermoid carcinoma cell line was used. MUC5AC mRNA and protein were measured using the RT-PCR and Western blot analysis. The activation of mitogen activated protein kinases (MAPKs) were determined by means of the Western blot analysis. Results:MUC5AC was induced by treating the NCI-H292 cells with 10 ng/ml of IL-1β for 24 hours. A pre-treatment of 200 μg/ml of EGb 761 significantly suppressed the IL-1β induced MUC5AC expression. The inhibition of MUC5AC gene expression by EGb 761 was noted to be suppressed via both the extracellular signal-regulated kinase (ERK) and the p38 MAPK pathways in a kinase-specific inhibitor study. Conclusion:EGb 761 suppresses IL-1β-induced MUC5AC gene expression in the human airway epithelial cells. Therefore, it may be considered as a possible anti-hypersecretory agent.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96526
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