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은행잎 추출물(EGb 761)에 의한 IL -1β 유도 MUC5AC 유전자 발현의 억제

DC Field Value Language
dc.contributor.author김경수-
dc.date.accessioned2014-12-21T16:52:50Z-
dc.date.available2014-12-21T16:52:50Z-
dc.date.issued2007-
dc.identifier.issn1229-1498-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96526-
dc.description.abstractBackground and Objectives:The purpose of this study is to investigate whether Ginkgo biloba extract (EGb 761) can suppress IL-1β-induced MUC5AC gene expression in NCI-H292 human airway epithelial cells and to discover what its possible mechanism is. Materials and Methods:NCI-H292 human pulmonary mucoepidermoid carcinoma cell line was used. MUC5AC mRNA and protein were measured using the RT-PCR and Western blot analysis. The activation of mitogen activated protein kinases (MAPKs) were determined by means of the Western blot analysis. Results:MUC5AC was induced by treating the NCI-H292 cells with 10 ng/ml of IL-1β for 24 hours. A pre-treatment of 200 μg/ml of EGb 761 significantly suppressed the IL-1β induced MUC5AC expression. The inhibition of MUC5AC gene expression by EGb 761 was noted to be suppressed via both the extracellular signal-regulated kinase (ERK) and the p38 MAPK pathways in a kinase-specific inhibitor study. Conclusion:EGb 761 suppresses IL-1β-induced MUC5AC gene expression in the human airway epithelial cells. Therefore, it may be considered as a possible anti-hypersecretory agent.-
dc.description.statementOfResponsibilityopen-
dc.format.extent49~55-
dc.languageEnglish-
dc.publisherKorean Rhinologic Society-
dc.relation.isPartOfJournal of Rhinology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title은행잎 추출물(EGb 761)에 의한 IL -1β 유도 MUC5AC 유전자 발현의 억제-
dc.title.alternativeSuppression of IL-1β-induced MUG5AC Gene Expression by Ginkgo biloba Extract(EGb 761) in Human Airway Epithelial Cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthor장정현-
dc.contributor.googleauthor김정홍-
dc.contributor.googleauthor김경수-
dc.contributor.googleauthor전주현-
dc.contributor.googleauthor조창일-
dc.contributor.googleauthor이근완-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00298-
dc.relation.journalcodeJ01739-
dc.subject.keywordGinkgo biloba extract 761-
dc.subject.keywordInterleukin-1β-
dc.subject.keywordMucins-
dc.subject.keywordEpithelial cells-
dc.contributor.alternativeNameKim, Kyung Su-
dc.contributor.affiliatedAuthorKim, Kyung Su-
dc.rights.accessRightsfree-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage49-
dc.citation.endPage55-
dc.identifier.bibliographicCitationJournal of Rhinology, Vol.14(1) : 49-55, 2007-
dc.identifier.rimsid36140-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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