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은행잎 추출물(EGb 761)에 의한 IL -1β 유도 MUC5AC 유전자 발현의 억제
DC Field | Value | Language |
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dc.contributor.author | 김경수 | - |
dc.date.accessioned | 2014-12-21T16:52:50Z | - |
dc.date.available | 2014-12-21T16:52:50Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1229-1498 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96526 | - |
dc.description.abstract | Background and Objectives:The purpose of this study is to investigate whether Ginkgo biloba extract (EGb 761) can suppress IL-1β-induced MUC5AC gene expression in NCI-H292 human airway epithelial cells and to discover what its possible mechanism is. Materials and Methods:NCI-H292 human pulmonary mucoepidermoid carcinoma cell line was used. MUC5AC mRNA and protein were measured using the RT-PCR and Western blot analysis. The activation of mitogen activated protein kinases (MAPKs) were determined by means of the Western blot analysis. Results:MUC5AC was induced by treating the NCI-H292 cells with 10 ng/ml of IL-1β for 24 hours. A pre-treatment of 200 μg/ml of EGb 761 significantly suppressed the IL-1β induced MUC5AC expression. The inhibition of MUC5AC gene expression by EGb 761 was noted to be suppressed via both the extracellular signal-regulated kinase (ERK) and the p38 MAPK pathways in a kinase-specific inhibitor study. Conclusion:EGb 761 suppresses IL-1β-induced MUC5AC gene expression in the human airway epithelial cells. Therefore, it may be considered as a possible anti-hypersecretory agent. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 49~55 | - |
dc.language | English | - |
dc.publisher | Korean Rhinologic Society | - |
dc.relation.isPartOf | Journal of Rhinology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 은행잎 추출물(EGb 761)에 의한 IL -1β 유도 MUC5AC 유전자 발현의 억제 | - |
dc.title.alternative | Suppression of IL-1β-induced MUG5AC Gene Expression by Ginkgo biloba Extract(EGb 761) in Human Airway Epithelial Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | 장정현 | - |
dc.contributor.googleauthor | 김정홍 | - |
dc.contributor.googleauthor | 김경수 | - |
dc.contributor.googleauthor | 전주현 | - |
dc.contributor.googleauthor | 조창일 | - |
dc.contributor.googleauthor | 이근완 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00298 | - |
dc.relation.journalcode | J01739 | - |
dc.subject.keyword | Ginkgo biloba extract 761 | - |
dc.subject.keyword | Interleukin-1β | - |
dc.subject.keyword | Mucins | - |
dc.subject.keyword | Epithelial cells | - |
dc.contributor.alternativeName | Kim, Kyung Su | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Su | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 55 | - |
dc.identifier.bibliographicCitation | Journal of Rhinology, Vol.14(1) : 49-55, 2007 | - |
dc.identifier.rimsid | 36140 | - |
dc.type.rims | ART | - |
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