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Changes in Serum and Ascitic Monocyte Chemotactic Protein-1 (MCP-1) and IL-10 Levels in Cirrhotic Patients with Spontaneous Bacterial Peritonitis

Authors
 Ja Kyung Kim  ;  Chae Yoon Chon  ;  Young Myoung Moon  ;  Kwang-Hyub Han  ;  Sang Hoon Ahn  ;  Seung Min Bang  ;  Jae Hee Cho  ;  Yoon Jae Kim  ;  Jae Hak Kim 
Citation
 JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, Vol.27(3) : 227-230, 2007 
Journal Title
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
ISSN
 1079-9907 
Issue Date
2007
Abstract
Spontaneous bacterial peritonitis (SBP) is a prototypical infectious disease of cirrhotic patients. It has been suggested that cirrhotic patients' response to infection is less effective because of differences in the inflammatory and immune reactions. This study aimed to investigate the expression of the inflammatory cytokines monocyte chemotactic protein-1 (MCP-1) and interleukin-10 (IL-10) in cirrhotic patients with SBP. The MCP1 and IL-10 levels in the sera and ascitic fluids of cirrhotic patients with (n = 40) or without SBP (n=17) were serially analyzed by ELISA. In the non-SBP group, the mean MCP-1 levels in sera and ascites were 53.0 +/- 45.8 pg/mL and 197.5 +/- 109.5 pg/mL, respectively, and the IL-10 levels were 10.9 +/- 9.5 pg/mL and 77.6 +/- 79.7 pg/mL, respectively. In the SBP group, the mean MCP-1 levels in serum and ascites before treatment were 164.7 +/- 126.4 pg/mL and 365.3 +/- 583.0 pg/mL, respectively, and the IL-10 levels were 31.4 +/- 44.1 pg/mL and 188.1 +/- 189.5 pg/mL, respectively. The sera MCP-1 and ascites IL-10 levels differed significantly between the two groups. In the SBP group, sera and ascitic MCP-1 and IL-10 levels fell during treatment. The low MCP-1 and IL-10 levels on the seventh day of treatment were found to have a statistically significant relationship to patient survival. MCP-1 and IL-10 levels in sera and ascites may be related to the clinical course of SBP.
Full Text
http://online.liebertpub.com/doi/abs/10.1089/jir.2006.0055
DOI
10.1089/jir.2006.0055
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yoon Jae(김윤재)
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Kim, Jae Hak(김재학)
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Chon, Chae Yoon(전재윤)
Cho, Jae Hee(조재희) ORCID logo https://orcid.org/0000-0003-4174-0091
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96350
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