87 277

Cited 0 times in

Use of the Putamen/Caudate Volume Ratio for Early Differentiation between Parkinsonian Variant of Multiple System Atrophy and Parkinson Disease

 Ha Y. Shin  ;  Suk Y. Kang  ;  Young H. Sohn  ;  Myung-Sik Lee  ;  Hyun-Sook Kim  ;  Jae H. Yang 
 Journal of Clinical Neurology, Vol.3(2) : 79-81, 2007 
Journal Title
 Journal of Clinical Neurology 
Issue Date
Parkinson’s disease ; Multiple system atrophy ; Putamen ; Brain MRI
BACKGROUND AND PURPOSE: Neuropathological studies have demonstrated that multiple system atrophy (MSA) produces selective atrophy of the putamen with sparing of the caudate nucleus, while both structures are spared in idiopathic Parkinson's disease (PD). In this study we evaluated the clinical efficacy of using putaminal atrophy in brain MRI to differentiate MSA and PD. METHODS: We measured the putamen/caudate volume ratio on brain MRI in 24 patients with MSA and 21 patients with PD. Two clinicians who were blinded to the patients' diagnoses and to each other's assessments measured the volume ratio using a computer program. RESULTS: The measured volume ratios of the two investigators were highly correlated (r=0.72, p<0.0001). The volume ratio was significantly lower in MSA (1.29+/-0.28) than PD (1.91+/-0.29, p<0.0001). Setting an arbitrary cutoff ratio of 1.6 resulted in about 90% of patients with MSA falling into the group with a lower ratio, whereas more than 80% of patients with PD belonged to the other group. CONCLUSIONS: The present results demonstrate that putaminal atrophy in MSA as measured on brain MRI represents an effective tool for differentiating MSA from PD.
Files in This Item:
T200701676.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Yang, Jae Hoon(양재훈)
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.