Cited 56 times in
Switching monopolar radiofrequency ablation technique using multiple, internally cooled electrodes and a multichannel generator - Ex vivo and in vivo pilot study
DC Field | Value | Language |
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dc.contributor.author | 최진영 | - |
dc.date.accessioned | 2014-12-21T16:42:43Z | - |
dc.date.available | 2014-12-21T16:42:43Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0020-9996 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96207 | - |
dc.description.abstract | OBJECTIVE: We sought to determine the optimal switching time and interprobe distance for creating a large coagulation zone in the liver by switching monopolar radiofrequency ablation (RFA) technique using a prototype multichannel radiofrequency generator and multiple electrodes. MATERIALS AND METHODS: Using 3, 17-gauge, internally cooled electrodes and a prototype multichannel radiofrequency (RF) generator to allow automatic switching of RF energy among 3 electrodes according to their impedance changes, RF energy was applied in a switching monopolar mode to explanted bovine livers or to the livers of 7 dogs. In the ex vivo study, we evaluated the effect of the switching time (5, 15, 30, and 60 seconds) and the interprobe distance (3 cm and 4 cm) on the mean volume of the ablation zone using the switching RFA; we then compared the ablation volume of the switching RFA group (12 minutes) with that of the overlapping RFA group (12 minutes x 3 = 36 minutes). In our preliminary in vivo experiments using 2 dogs, the electrodes were placed in a triangular array (spacing 2 cm, 3 cm, 3.5 cm, or 4 cm) and were activated for 12 minutes or 20 minutes in a monopolar mode (power output 200 W). In our primary experiments using 5 dogs, RFA in a switching mode created 10 coagulation zones at a 2- to 3-cm interprobe distance. The duration of the RFA was 12 minutes. The size and geometry of the coagulation zone also were assessed. RESULTS: In this ex vivo study, switching monopolar RFA at a 3-cm interprobe distance and at a 30-second switching time allowed the creation of a large, confluent ablation zone. There was no significant difference in the mean ablation volume between the overlapping (72.9 +/- 12.6(3) cm) and the switching RFA groups (65.7 +/- 12.6 cm(3); P>0.05). In the preliminary in vivo experiments, RFA created spherical coagulations at interprobe distances of 2 cm and 3 cm but at larger distances than 3 cm, RFA created partially confluent coagulation zones. In our principal experiments, switching RFA created areas of well-defined coagulation, ie, at a 2-cm interprobe distance, the volume and short-axis coagulation diameter were 35.5+/- 5.7(3) cm and 4.6 +/- 0.5 cm, respectively, whereas at 3 cm, they were 40.7 +/- 12.8(3) cm and 4.8 +/- 0.8 cm, respectively. The mean values of the circularity (isometric ratio) of the coagulation at the 2- and 3-cm interprobe distances were 0.95 +/- 0.02, and 0.85+/- 0.06, respectively. CONCLUSIONS: Our study demonstrated that switching monopolar RFA using the multichannel RF system at a 2- or 3-cm interprobe distance and at a 30-second switching time can create a large, confluent coagulation zone in the liver within a clinically acceptable time frame. We believe that this technology will provide a useful tool for the treatment of large liver tumors. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 163~171 | - |
dc.relation.isPartOf | INVESTIGATIVE RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blood Coagulation* | - |
dc.subject.MESH | Catheter Ablation/instrumentation | - |
dc.subject.MESH | Catheter Ablation/methods* | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Electrodes* | - |
dc.subject.MESH | Liver/physiology | - |
dc.subject.MESH | Liver Neoplasms/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Necrosis | - |
dc.subject.MESH | Pilot Projects | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Whole Blood Coagulation Time | - |
dc.title | Switching monopolar radiofrequency ablation technique using multiple, internally cooled electrodes and a multichannel generator - Ex vivo and in vivo pilot study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Jeong Min Lee | - |
dc.contributor.googleauthor | Joon Koo Han | - |
dc.contributor.googleauthor | Byung Ihn Choi | - |
dc.contributor.googleauthor | Jin Young Choi | - |
dc.contributor.googleauthor | Se Hyung Kim | - |
dc.contributor.googleauthor | Young Hun Choi | - |
dc.contributor.googleauthor | Hyo Cheol Kim | - |
dc.identifier.doi | 10.1097/01.rli.0000252495.44818.b3 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04200 | - |
dc.relation.journalcode | J01188 | - |
dc.identifier.eissn | 1536-0210 | - |
dc.identifier.pmid | 17287646 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004424-200703000-00003&LSLINK=80&D=ovft | - |
dc.subject.keyword | liver | - |
dc.subject.keyword | interventional procedures | - |
dc.subject.keyword | radiofrequency ablation | - |
dc.subject.keyword | experimental study | - |
dc.contributor.alternativeName | Choi, Jin Young | - |
dc.contributor.affiliatedAuthor | Choi, Jin Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 42 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 163 | - |
dc.citation.endPage | 171 | - |
dc.identifier.bibliographicCitation | INVESTIGATIVE RADIOLOGY, Vol.42(3) : 163-171, 2007 | - |
dc.identifier.rimsid | 34975 | - |
dc.type.rims | ART | - |
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