2 428

Cited 22 times in

Evaluation of the prognostic value of Okuda, Cancer of the Liver Italian Program, and Japan Integrated Staging systems for hepatocellular carcinoma patients undergoing radiotherapy

Authors
 Jinsil Seong  ;  Su Jung Shim  ;  Sang Hoon Ahn  ;  Chae Yoon Chon  ;  Kwang Hyub Han  ;  Ik Jae Lee 
Citation
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.67(4) : 1037-1042, 2007 
Journal Title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
ISSN
 0360-3016 
Issue Date
2007
MeSH
Adult ; Aged ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology* ; Carcinoma, Hepatocellular/radiotherapy ; Female ; Humans ; Italy ; Japan ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology* ; Liver Neoplasms/radiotherapy ; Male ; Middle Aged ; Neoplasm Staging/methods* ; Prognosis ; Reproducibility of Results ; Retrospective Studies ; Survival Analysis ; Survival Rate
Keywords
Staging system ; Hepatocellular carcinoma ; Radiotherapy ; Prognosis
Abstract
PURPOSE:
The purpose of this study was to compare the validity of staging systems, as well as to identify the staging system with the best prognostic value, in hepatocellular carcinoma (HCC) patients treated with radiotherapy.
METHODS AND MATERIALS:
From 1992 to 2003, a total of 305 patients undergoing radiotherapy for HCC were evaluated retrospectively. All patients were classified before radiation therapy by the following systems: tumor-node-metastasis (TNM), Okuda, Cancer of the Liver Italian Program (CLIP), and Japan Integrated Staging (JIS) score. Cumulative survival rates were obtained using the Kaplan-Meier method, and were statistically compared using the log-rank test.
RESULTS:
Median survival time was 11 months. The 1-, 2-, 3-, 4-, and 5-year survival rates were 45.1%, 24.5%, 14.7%, 10.3%, and 6.4%, respectively. Significant differences in survival were observed between all TNM stages, between CLIP scores 2, 3 and 5, 6, as well as between JIS scores 1, 2, and 2, 3.
CONCLUSIONS:
Among the systems studied, the TNM staging approach appeared to be the best predictor of prognosis. Staging systems that reflect liver disease status (Okuda stage, CLIP, and JIS score) showed limitations in stratifying patients undergoing radiotherapy into different prognostic groups.
Full Text
http://www.sciencedirect.com/science/article/pii/S0360301606033761
DOI
10.1016/j.ijrobp.2006.10.035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Shim, Su Jung(심수정)
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Ik Jae(이익재) ORCID logo https://orcid.org/0000-0001-7165-3373
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96192
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links