2 333

Cited 57 times in

A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation

Authors
 Nam Kyu Kim  ;  Seung Hyuk Baik  ;  Hyun Cheol Chung  ;  Sun Young Rha  ;  Ki Chang Keum  ;  Jinsil Seong  ;  Hogeun Kim  ;  Yun Jung Choi  ;  Hong Ryull Pyo  ;  Byung Soh Min 
Citation
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.67(1) : 204-210, 2007 
Journal Title
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 
ISSN
 0360-3016 
Issue Date
2007
MeSH
Adult ; Aged ; Combined Modality Therapy/methods ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Staging/methods ; Prospective Studies ; Rectal Neoplasms*/drug therapy ; Rectal Neoplasms*/pathology ; Rectal Neoplasms*/radiotherapy ; Rectal Neoplasms*/surgery ; Remission Induction ; Statistics, Nonparametric ; Ultrasonography
Keywords
Rectal cancer ; Preoperative chemoradiotherapy ; Tumor volume ; Histopathologic downstaging ; Tumor regression grade
Abstract
Purpose: To compare tumor volume reduction rate, histopathologic downstaging, and tumor regression grade (TRG) among tumor responses in rectal cancer after preoperative chemoradiotherapy (CRT). Patients and Methods: Between 2002 and 2004, 30 patients with locally advanced rectal cancer underwent preoperative CRT, followed by surgical resection. Magnetic resonance volumetry was performed before and after CRT. Histopathologic tumor staging and tumor regression were reviewed. We compared pre- and post-CRT tumor volume and percent of volume reduction, according to histopathologic downstaging and TRG. Results: The tumor volume reduction rates ranged from 14.6% to 100%. Mean pre- and post-CRT tumor volumes were significantly smaller in patients who showed T downstaging than in those who did not (p = 0.040, 0.014). The mean tumor volume reduction was 66.4% vs. 55.2% (p = 0.361). However, the mean pre- and post-CRT tumor volume and mean tumor volume reduction rate between patients who showed N downstaging and those who did not were not statistically different (p = 0.176, 0.767, and 0.899). With respect to TRG, the mean pre- and post-CRT tumor volumes were not statistically significant (p = 0.108, 0.708, and 0.120). Conclusion: Tumor volume reduction rate does not correlate with histopathologic downstaging and TRG. It might be hazardous to evaluate tumor response with respect to volume reduction and to select the surgical method on this basis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0360301606027696
DOI
10.1016/j.ijrobp.2006.08.020
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Hogeun(김호근)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Pyo, Hong Ryull(표홍렬)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96186
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links