Cited 63 times in
A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation
DC Field | Value | Language |
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dc.contributor.author | 성진실 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 표홍렬 | - |
dc.contributor.author | 금기창 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 백승혁 | - |
dc.date.accessioned | 2014-12-21T16:42:05Z | - |
dc.date.available | 2014-12-21T16:42:05Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96186 | - |
dc.description.abstract | Purpose: To compare tumor volume reduction rate, histopathologic downstaging, and tumor regression grade (TRG) among tumor responses in rectal cancer after preoperative chemoradiotherapy (CRT). Patients and Methods: Between 2002 and 2004, 30 patients with locally advanced rectal cancer underwent preoperative CRT, followed by surgical resection. Magnetic resonance volumetry was performed before and after CRT. Histopathologic tumor staging and tumor regression were reviewed. We compared pre- and post-CRT tumor volume and percent of volume reduction, according to histopathologic downstaging and TRG. Results: The tumor volume reduction rates ranged from 14.6% to 100%. Mean pre- and post-CRT tumor volumes were significantly smaller in patients who showed T downstaging than in those who did not (p = 0.040, 0.014). The mean tumor volume reduction was 66.4% vs. 55.2% (p = 0.361). However, the mean pre- and post-CRT tumor volume and mean tumor volume reduction rate between patients who showed N downstaging and those who did not were not statistically different (p = 0.176, 0.767, and 0.899). With respect to TRG, the mean pre- and post-CRT tumor volumes were not statistically significant (p = 0.108, 0.708, and 0.120). Conclusion: Tumor volume reduction rate does not correlate with histopathologic downstaging and TRG. It might be hazardous to evaluate tumor response with respect to volume reduction and to select the surgical method on this basis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 204~210 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging/methods | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Rectal Neoplasms*/drug therapy | - |
dc.subject.MESH | Rectal Neoplasms*/pathology | - |
dc.subject.MESH | Rectal Neoplasms*/radiotherapy | - |
dc.subject.MESH | Rectal Neoplasms*/surgery | - |
dc.subject.MESH | Remission Induction | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.subject.MESH | Ultrasonography | - |
dc.title | A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Seung Hyuk Baik | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.contributor.googleauthor | Hogeun Kim | - |
dc.contributor.googleauthor | Yun Jung Choi | - |
dc.contributor.googleauthor | Hong Ryull Pyo | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.identifier.doi | 10.1016/j.ijrobp.2006.08.020 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A04245 | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A01827 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J01157 | - |
dc.identifier.eissn | 1879-355X | - |
dc.identifier.pmid | 17084555 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0360301606027696 | - |
dc.subject.keyword | Rectal cancer | - |
dc.subject.keyword | Preoperative chemoradiotherapy | - |
dc.subject.keyword | Tumor volume | - |
dc.subject.keyword | Histopathologic downstaging | - |
dc.subject.keyword | Tumor regression grade | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Pyo, Hong Ryull | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Min, Byung Soh | - |
dc.contributor.alternativeName | Baik, Seung Hyuk | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Pyo, Hong Ryull | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Min, Byung Soh | - |
dc.contributor.affiliatedAuthor | Baik, Seung Hyuk | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 67 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 204 | - |
dc.citation.endPage | 210 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.67(1) : 204-210, 2007 | - |
dc.identifier.rimsid | 34962 | - |
dc.type.rims | ART | - |
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