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Association between estrogen receptor polymorphism and pain susceptibility in female temporomandibular joint osteoarthritis patients

 S.-C. Kang  ;  D.-G. Lee  ;  H.-J. Ahn  ;  Y.-K. Kim  ;  S.T. Kim  ;  J.-H. Choi 
 International Journal of Oral and Maxillofacial Surgery, Vol.36(5) : 391-394, 2007 
Journal Title
 International Journal of Oral and Maxillofacial Surgery 
Issue Date
Adolescent ; Adult ; Case-Control Studies ; Estrogen Receptor alpha/genetics* ; Facial Pain/genetics ; Facial Pain/physiopathology* ; Female ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Haplotypes/genetics ; Humans ; Middle Aged ; Osteoarthritis/genetics ; Osteoarthritis/physiopathology* ; Pain Measurement ; Polymorphism, Genetic/genetics* ; Polymorphism, Restriction Fragment Length ; Temporomandibular Joint Disorders/genetics ; Temporomandibular Joint Disorders/physiopathology*
Estrogen receptor alpha (ERα) ; polymorphism ; temporomandibular joint (TMJ) ; osteoarthritis (OA) ; pain
The purpose of this study was to investigate the possible association between estrogen receptor alpha (ERα) polymorphism and pain susceptibility in female symptomatic temporomandibular joint (TMJ) osteoarthritis (OA) patients. A patient group of 100 women, diagnosed as TMJ OA according to the research diagnostic criteria for temporomandibular disorders, were selected, and 74 women with no signs and symptoms of temporomandibular disorder were assigned to a control group. Pvu II and Xba I restriction fragment length polymorphisms were analyzed by direct haplotyping. The patient group was divided into three subgroups according to a visual analog scale (VAS): mild pain (0 ≤ VAS < 4); moderate pain (4 ≤ VAS < 7); severe pain (7 ≤ VAS ≤ 10). Frequencies of genotypes and haplotypes in the patient and control groups were compared, and the association between pain intensity and copy numbers of PX haplotype were evaluated using the chi-square test. No significant differences in genotype and haplotype frequencies were observed between the patient and control groups (p > .05). TMJ OA patients carrying the PX haplotype were found to have a significantly higher risk of moderate or severe pain compared to those without the PX haplotype, suggesting that ERα polymorphism may be associated with pain susceptibility in female TMJ OA patients.
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2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Taek(김성택)
Ahn, Hyoung Joon(안형준)
Choi, Jong Hoon(최종훈) ORCID logo https://orcid.org/0000-0003-3211-3619
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