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Association between estrogen receptor polymorphism and pain susceptibility in female temporomandibular joint osteoarthritis patients

DC FieldValueLanguage
dc.contributor.author김성택-
dc.contributor.author안형준-
dc.contributor.author최종훈-
dc.date.accessioned2014-12-21T16:41:57Z-
dc.date.available2014-12-21T16:41:57Z-
dc.date.issued2007-
dc.identifier.issn0901-5027-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96182-
dc.description.abstractThe purpose of this study was to investigate the possible association between estrogen receptor alpha (ERα) polymorphism and pain susceptibility in female symptomatic temporomandibular joint (TMJ) osteoarthritis (OA) patients. A patient group of 100 women, diagnosed as TMJ OA according to the research diagnostic criteria for temporomandibular disorders, were selected, and 74 women with no signs and symptoms of temporomandibular disorder were assigned to a control group. Pvu II and Xba I restriction fragment length polymorphisms were analyzed by direct haplotyping. The patient group was divided into three subgroups according to a visual analog scale (VAS): mild pain (0 ≤ VAS < 4); moderate pain (4 ≤ VAS < 7); severe pain (7 ≤ VAS ≤ 10). Frequencies of genotypes and haplotypes in the patient and control groups were compared, and the association between pain intensity and copy numbers of PX haplotype were evaluated using the chi-square test. No significant differences in genotype and haplotype frequencies were observed between the patient and control groups (p > .05). TMJ OA patients carrying the PX haplotype were found to have a significantly higher risk of moderate or severe pain compared to those without the PX haplotype, suggesting that ERα polymorphism may be associated with pain susceptibility in female TMJ OA patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent391~394-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHEstrogen Receptor alpha/genetics*-
dc.subject.MESHFacial Pain/genetics-
dc.subject.MESHFacial Pain/physiopathology*-
dc.subject.MESHFemale-
dc.subject.MESHGene Frequency/genetics-
dc.subject.MESHGenetic Predisposition to Disease/genetics-
dc.subject.MESHHaplotypes/genetics-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOsteoarthritis/genetics-
dc.subject.MESHOsteoarthritis/physiopathology*-
dc.subject.MESHPain Measurement-
dc.subject.MESHPolymorphism, Genetic/genetics*-
dc.subject.MESHPolymorphism, Restriction Fragment Length-
dc.subject.MESHTemporomandibular Joint Disorders/genetics-
dc.subject.MESHTemporomandibular Joint Disorders/physiopathology*-
dc.titleAssociation between estrogen receptor polymorphism and pain susceptibility in female temporomandibular joint osteoarthritis patients-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral diagnosis (구강내과학)-
dc.contributor.googleauthorS.-C. Kang-
dc.contributor.googleauthorD.-G. Lee-
dc.contributor.googleauthorH.-J. Ahn-
dc.contributor.googleauthorY.-K. Kim-
dc.contributor.googleauthorS.T. Kim-
dc.contributor.googleauthorJ.-H. Choi-
dc.identifier.doi10.1016/j.ijom.2006.12.004-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00588-
dc.contributor.localIdA02273-
dc.contributor.localIdA04188-
dc.relation.journalcodeJ01143-
dc.identifier.eissn1399-0020-
dc.identifier.pmid17391927-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0901502706005091-
dc.subject.keywordEstrogen receptor alpha (ERα)-
dc.subject.keywordpolymorphism-
dc.subject.keywordtemporomandibular joint (TMJ)-
dc.subject.keywordosteoarthritis (OA)-
dc.subject.keywordpain-
dc.contributor.alternativeNameKim, Seong Taek-
dc.contributor.alternativeNameAhn, Hyoung Joon-
dc.contributor.alternativeNameChoi, Jong Hoon-
dc.contributor.affiliatedAuthorKim, Seong Taek-
dc.contributor.affiliatedAuthorAhn, Hyoung Joon-
dc.contributor.affiliatedAuthorChoi, Jong Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume36-
dc.citation.number5-
dc.citation.startPage391-
dc.citation.endPage394-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.36(5) : 391-394, 2007-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers

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