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The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population

Authors
 Jae-Youn Moon  ;  Sungha Park  ;  Ji-Hyuk Rhee  ;  Sun Ha Jee  ;  Chan Mi Park  ;  Dae-Sik Choi  ;  Hyun-Young Park  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Namsik Chung 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.114(1) : 83-89, 2007 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOLOGY 
ISSN
 0167-5273 
Issue Date
2007
MeSH
Coronary Artery Disease/complications* ; Female ; Humans ; Korea/epidemiology ; Male ; Metabolic Syndrome/classification* ; Metabolic Syndrome/complications* ; Metabolic Syndrome/epidemiology ; Middle Aged ; Risk Factors
Keywords
Metabolic syndrome ; NCEP criteria ; WHO criteriaInsulin resistance ; Coronary artery disease
Abstract
BACKGROUND: We compared the metabolic profiles and risk of coronary artery disease (CAD) in Koreans with non-diabetic metabolic syndrome (MetS). [We applied four criteria of MetS: the NCEP criteria, the Asian modified NCEP (a-NCEP) criteria, the WHO criteria and the Asian modified WHO (a-WHO).] METHODS: The study group composed of 2724 subjects enrolled in the cardiovascular genome center. There were 728 patients with significant CAD. The different criteria of the MetS were applied for the study population. RESULTS: Among the 2724 participants, 522 (19.2%) met the NCEP criteria, 796 (29.2%) met the a-NCEP criteria, 361 (13.3%) met the WHO criteria and 576 (21.1%) met the a-WHO criteria. The clinical parameters, lipid profile, apoA1 and apoB level were not different between the participants classified as MetS by using the different criteria. The odds ratio for CAD prediction were not significantly different according to the metabolic criteria (odd ratio: 1.755 [95% CI: 1.423-2.163] in NCEP criteria, 2.120 [1.763-2.549] in a-NCEP criteria, 1.854 [1.466-2.343] in WHO criteria, 2.205 [1.810-2.687] in a-WHO criteria). The serum level of apoA1 and apoB showed strong correlations with MetS classified by all criteria and the HOMA index and insulin level showed better correlations with WHO-MetS criteria. CONCLUSIONS: All the MetS criteria showed similar metabolic profiles and all four criteria had similar predictive value for CAD. Conventional MetS criteria, applied to the non-diabetic Asian population, may underestimate the population at risk. Our data suggests that the Asian modified criteria will decrease the risk for underdiagnosis while demonstrating similar metabolic profiles and CAD risk compared to the conventional criteria.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167527306001677
DOI
10.1016/j.ijcard.2005.12.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Moon, Jae Youn(문재연)
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Park, Hyun Young(박현영)
Rhee, Ji Hyuk(이지혁)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
Choi, Dae Sik(최대식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96146
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