2 202

Cited 3 times in

Extracellular signal-regulated kinase induces phosphorylation of IκBα in Helicobacter pylori-infected gastric epithelial AGS cells

Authors
 S. O. Cho  ;  K. H. Kim  ;  H. Kim 
Citation
 INFLAMMOPHARMACOLOGY, Vol.15(1) : 26-30, 2007 
Journal Title
 INFLAMMOPHARMACOLOGY 
ISSN
 0925-4692 
Issue Date
2007
MeSH
Bacterial Proteins/metabolism ; Cell Line, Tumor ; DNA, Bacterial* ; Epithelial Cells/enzymology ; Gastric Mucosa/enzymology ; Helicobacter Infections/pathology* ; Helicobacter pylori/pathogenicity* ; Humans ; I-kappa B Kinase/metabolism* ; Mitogen-Activated Protein Kinases/metabolism* ; NF-kappa B/metabolism* ; Phosphorylation
Abstract
In Helicobacter pylori (H. pylori)-induced gastric ulceration, NF-κB regulates the expression of inflammatory genes. NF-κB is activated by phsophorylation of its endogenous inhibitor, IκBα. The possible involvement of mitogenactivated protein kinase (MAPK) on NF-κB activation has been suggested in various cells. Present study aims to investigate whether H. pylori in a Korean isolate induces phosphorylation of IkBα and whether H. pylori-induced phosphorylation of IkBα is mediated by MAPK in gastric epithelial AGS cells. AGS cells were treated with MAPK inhibitors (U0126 for extracellular signal-regulated kinase, SB203580 for p38 kinase, SP600125 for c-Jun NH2-terminal protein kinases) and stimulated with H. pylori. As a result, H. pylori increased phospho-specific IκBα accompanied with the decrease in control IκBα. H. pylori-induced phosphorylation of IκBα was inhibited by treatment of U0126, but not by SB203580 or SP600125. In conclusion, extracellular signal-regulated kinase induces phosphorylation of IκBα in H. pylori-infected AGS cells.
Full Text
http://link.springer.com/article/10.1007/s10787-006-1547-z
DOI
10.1007/s10787-006-1547-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96116
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse