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Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations

Authors
 Ji Wan Park  ;  Iain McIntosh  ;  Terri H. Beaty  ;  Alan F. Scott  ;  Roxann Ingersoll  ;  M. Daniele Fallin  ;  Beyoung Yun Park  ;  Sun Ha Jee  ;  Vincent Yeow  ;  Samuel S. Chong  ;  Philip K. Chen  ;  Yah-Huei Wu-Chou  ;  Craig A. Vander Kolk  ;  Ethylin Wang Jabs  ;  MS  ;  Jacqueline B. Hetmanski 
Citation
 GENETICS IN MEDICINE, Vol.9(4) : 219-227, 2007 
Journal Title
 GENETICS IN MEDICINE 
ISSN
 1098-3600 
Issue Date
2007
Abstract
PURPOSE: The interferon regulatory factor 6 (IRF6), the gene that causes van der Woude syndrome has been shown to be associated with nonsyndromic cleft lip with or without palate in several populations. This study aimed to confirm the contribution of IRF6 to cleft lip with or without palate risk in additional Asian populations. METHODS: A set of 13 single nucleotide polymorphisms was tested for association with cleft lip with or without palate in 77 European American, 146 Taiwanese, 34 Singaporean, and 40 Korean case-parent trios using both the transmission disequilibrium test and conditional logistic regression models. RESULTS: Evidence of linkage and association was observed among all four populations; and two specific haplotypes [GC composed of rs2235373-rs2235371 (p.V274I) and AAG of rs599021-rs2235373-rs595918] showed the most significant over- and undertransmission among Taiwanese cases (P=9x10(-6) and P=5x10(-6), respectively). The AGC/CGC diplotype composed of rs599021-rs2235373-rs2013162 showed almost a 7-fold increase in risk among the Taiwanese sample (P<10(-3)). These results confirmed the contribution of this gene to susceptibility of oral clefts across different populations; however, the specific single nucleotide polymorphisms showing statistical significance differed among ethnic groups. CONCLUSION: The high-risk genotypes and diplotypes identified here may provide a better understanding of the etiological role of this gene in oral clefts and potential options for genetic counseling.
Files in This Item:
T200700781.pdf Download
DOI
10.1097/GIM.0b013e3180423cca
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Beyoung Yun(박병윤)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96053
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