5 258

Cited 18 times in

Anti-hepatitis A virus seroprevalence among patients with chronic viral liver disease in Korea

Authors
 Do Young Kim  ;  Sang Hoon Ahn  ;  Chae Yoon Chon  ;  Kwang Hyub Han  ;  Kwan Sik Lee  ;  Yong Han Paik  ;  Ja Kyung Kim  ;  Seung Up Kim  ;  Hyun Woong Lee 
Citation
 EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol.19(11) : 923-926, 2007 
Journal Title
 EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 
ISSN
 0954-691X 
Issue Date
2007
MeSH
Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/immunology ; Female ; Hepacivirus ; Hepatitis A/immunology* ; Hepatitis A Antibodies/blood* ; Hepatitis B virus ; Hepatitis B, Chronic/immunology ; Hepatitis C, Chronic/immunology ; Humans ; Korea/epidemiology ; Liver Cirrhosis/immunology* ; Liver Cirrhosis/virology* ; Liver Neoplasms/immunology ; Male ; Middle Aged ; Seroepidemiologic Studies ; Sex Distribution
Abstract
BACKGROUND/OBJECTIVE: It is generally recommended that patients with chronic viral hepatitis should be vaccinated against hepatitis A virus (HAV) infection. We intended to evaluate the prevalence of IgG anti-HAV according to age in patients chronically infected with hepatitis B virus or hepatitis C virus in Korea. METHODS: From June to October 2006, 303 patients (226 male, 77 female) with chronic hepatitis, liver cirrhosis, or hepatocellular carcinoma were recruited (mean age 50.8+/-14.4 years; range 16-84). The sera were tested for antibodies to HAV, and overall and age-specific seroprevalence of anti-HAV was assessed. RESULTS: Hepatitis B virus infection was the etiology of liver diseases in 267 patients (88.1%), with hepatitis C virus infection in 36 (11.9%). The distribution of clinical diagnosis was chronic hepatitis in 86 patients (28.4%), liver cirrhosis in 36 (11.9%), and hepatocellular carcinoma in 181 (57.9%). The patients were categorized by decade of age and the distribution was as follows: nine patients (2.5%) in their teens, 23 (6.2%) in their 20s, 36 (12.4%) in their 30s, 78 (25.7%) in their 40s, 72 (24.1%) in their 50s, and 85 (29%) >or=61 years. The overall seroprevalence of anti-HAV was 87.8% (266/303), and no difference was observed in sex (86.7 vs. 90.9%, P=0.42). The seroprevalence in each age group was 22.2, 26.1, 72.2, 97.4, 100 and 98.8%, respectively, showing marked increase in those over 40 years of age (P<0.001). CONCLUSION: Our study demonstrates that most Korean patients over 40 years of age with chronic liver disease have already been exposed to HAV.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042737-200711000-00003&LSLINK=80&D=ovft
DOI
10.1097/MEG.0b013e3282efa432
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Paik, Yong Han(백용한)
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95987
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse