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Use of a Modified Atkins Diet in Intractable Childhood Epilepsy

Authors
 Hoon-Chul Kang  ;  Hyun Sug Lee  ;  Heung Dong Kim  ;  Tae-Sung Ko  ;  Du Cheol Kang  ;  Su Jeong You 
Citation
 EPILEPSIA, Vol.48(1) : 182-186, 2007 
Journal Title
 EPILEPSIA 
ISSN
 0013-9580 
Issue Date
2007
MeSH
3-Hydroxybutyric Acid/blood ; 3-Hydroxybutyric Acid/metabolism ; Age Factors ; Child ; Cohort Studies ; Diet, Carbohydrate-Restricted/adverse effects ; Diet, Carbohydrate-Restricted/methods* ; Dietary Proteins/administration & dosage ; Disease-Free Survival ; Epilepsy/diet therapy* ; Epilepsy/metabolism ; Female ; Follow-Up Studies ; Humans ; Ketones/urine ; Ketosis/metabolism ; Male ; Prospective Studies ; Treatment Outcome
Abstract
PURPOSE: To evaluate the efficacy, safety and tolerability of a modified Atkins diet in intractable childhood epilepsy. METHODS: Fourteen children with epilepsy were treated prospectively with a modified Atkins diet. Outcome measures included seizure frequency, adverse reactions and tolerability to the diet; blood beta-hydroxybutyrate and urine ketones were also measured. RESULTS: Six months after diet initiation, seven (50%) remained on the diet, five (36%) had >50% seizure reduction, and three (21%) were seizure free. The diet was well tolerated by 12 (86%) patients. Most complications were transient and were successfully managed by careful follow-up and conservative strategies. A consistently strong ketosis (beta-hydroxybutyrate of >3 mmol/L) seemed to be important for maintaining the efficacy of the diet therapy. CONCLUSIONS: The modified Atkins diet was well tolerated and sometimes a modified Atkins diet can be substituted for the conventional ketogenic diet. Serious complications were rare, but long-term complications remain to be determined.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2006.00910.x/abstract
DOI
10.1111/j.1528-1167.2006.00910.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95972
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