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Comparison of lactated Ringer’s solution and 0.9% saline in the treatment of rhabdomyolysis induced by doxylamine intoxication

Authors
 Young Soon Cho  ;  Hoon Lim  ;  Seung Ho Kim 
Citation
 EMERGENCY MEDICINE JOURNAL, Vol.24(4) : 276-280, 2007 
Journal Title
 EMERGENCY MEDICINE JOURNAL 
ISSN
 1472-0205 
Issue Date
2007
MeSH
Adult ; Doxylamine/poisoning* ; Female ; Fluid Therapy/methods* ; Histamine H1 Antagonists/poisoning* ; Humans ; Isotonic Solutions/therapeutic use* ; Male ; Prospective Studies ; Rhabdomyolysis/chemically induced* ; Rhabdomyolysis/therapy* ; Ringer's Lactate ; Single-Blind Method ; Sodium Chloride/therapeutic use* ; Statistics, Nonparametric ; Treatment Outcome
Abstract
Objective: To compare the effectiveness and side effects of lactated Ringer’s solution (LR) and 0.9% saline (NS) in the treatment of rhabdomyolysis induced by doxylamine intoxication. Methods: In this 15-month-long prospective randomised single-blind study, after excluding 8 patients among 97 doxylamine-intoxicated patients, 28 (31%) patients were found to have developed rhabdomyolysis and were randomly allocated to NS group (n = 15) or LR group (n = 13). Results: After 12 h of aggressive hydration (400 ml/h), urine/serum pH was found to be significantly higher in the LR group, and serum Na+/Cl− levels to be significantly higher in the NS group. There were no significant differences in serum K+ level and in the time taken for creatine kinase normalisation. The amount of sodium bicarbonate administered and the frequency administration of diuretics was significantly higher in the NS group. Unlike the NS group, the LR group needed little supplemental sodium bicarbonate and did not develop metabolic acidosis. Conclusion: LR is more useful than NS in the treatment of rhabdomyolysis induced by doxylamine intoxication.
Files in This Item:
T200700988.pdf Download
DOI
10.1136/emj.2006.043265
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Ho(김승호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95964
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