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Preconditioning with Chronic Cerebral Hypoperfusion Reduces a Focal Cerebral Ischemic Injury and Increases Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 and Matrix Metalloproteinase-2 Expression

Authors
 Sun-Ah Choi  ;  Eun Hee Kim  ;  Ji Hoe Heo  ;  Byung In Lee  ;  Gyung Whan Kim  ;  Seo Hyun Kim  ;  Hyo Suck Nam  ;  Jong Yun Lee 
Citation
 CURRENT NEUROVASCULAR RESEARCH, Vol.4(2) : 89-97, 2007 
Journal Title
 CURRENT NEUROVASCULAR RESEARCH 
ISSN
 1567-2026 
Issue Date
2007
MeSH
Analysis of Variance ; Animals ; Brain Injuries/metabolism ; Brain Injuries/pathology ; Brain Injuries/physiopathology ; Brain Ischemia/metabolism* ; Brain Ischemia/physiopathology ; Brain Ischemia/prevention & control* ; DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism* ; Disease Models, Animal ; Gene Expression Regulation, Enzymologic/physiology* ; Ischemic Preconditioning/methods* ; Male ; Matrix Metalloproteinase 2/metabolism* ; Motor Activity/physiology ; Neurons/pathology ; Rats ; Rats, Inbred SHR ; Time Factors
Abstract
Atherosclerosis may cause severe stenosis of the arteries supplying the brain, which induces chronic cerebral hypoperfusion. Although an infarction often occurs in the chronically hypoperfused brain area, it has been uncertain whether the stroke severity is attenuated or increased when further decrease of blood flow occurs. To test the hypothesis that chronic cerebral hypoperfusion is protective against the subsequent severe ischemia, we examined the effect of chronic cerebral hypoperfusion on brains subjected to acute focal ischemia. Spontaneous hypertensive rats were subjected to middle cerebral artery occlusion/reperfusion four weeks after bilateral common carotid artery ligation (BCAL) or sham operation. The rats with BCAL had smaller infarctions, determined by 2,3,5- triphenyltetrazolium hydrochloride staining, and less severe neurologic deficits than those with sham operation. The number of DNAdamaged cells, examined by the in situ nick translation study, was significantly reduced in animals with BCAL. Immunoreactivity for apurinic/apyrimidinic endonuclease/redox factor-1, which plays a role in cellular defense mechanism, was markedly increased in those with BCAL. Indirect evidence of extracellular matrix remodeling, which might be associated with adaptive arteriogenesis or angiogenesis, was obtained in the form of increased matrix metalloproteinase-2 activity in them. These findings provide experimental evidence that chronic cerebral hypoperfusion would be protective against subsequent severe ischemic insults.
Full Text
http://www.eurekaselect.com/59198/article
DOI
10.2174/156720207780637252
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gyung Whan(김경환) ORCID logo https://orcid.org/0000-0001-7053-4372
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Lee, Byung In(이병인)
Lee, Jong Yun(이종윤)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95929
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