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Stimulated TNF-α release in macrophage and enhanced migration of dermal fibroblast by β-glucan

Authors
 Hyun Joo Son  ;  Dong-Wook Han  ;  Jong-Chul Park  ;  Yeon I Woo  ;  Mi Hee Lee  ;  Hye Ryeon Lim  ;  Hyun Sook Baek 
Citation
 CURRENT APPLIED PHYSICS, Vol.7(s1) : 33-36, 2007 
Journal Title
 CURRENT APPLIED PHYSICS 
ISSN
 1567-1739 
Issue Date
2007
Abstract
β-Glucan, a heterogeneous group of glucose polymers, modulates wound healing via macrophages, which are stimulated to release growth factors and cytokines, as well as via glucan receptors on fibroblasts, which are activated to migrate and synthesize collagen. The placement of β-glucan/collagen onto an arm of a young child with a scald burn improved healing of a partial-thickness burn wound. In this study, the effects of (1 → 3), (1 → 6)-β-d-glucan on the cytokine release in a macrophage cell line, RAW 264.7, were investigated. The effects of β-glucan on the proliferation and migration of adult human dermal fibroblasts (aHDFs) were also examined. When RAW 264.7 cells were treated with β-glucan, TNF-α secretion was stimulated in a dose-dependent manner, but IL-6 secretion was not. On the other hand, β-glucan treatment to aHDFs with 1 mg/ml resulted in a significant (p < 0.05) increase not in cell proliferation, but in cell migration. These results suggest that β-glucan can stimulate TNF-α release in macrophages and enhance fibroblast migration, which may accelerate wound healing.
Full Text
http://www.sciencedirect.com/science/article/pii/S1567173906002197
DOI
10.1016/j.cap.2006.11.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Baek, Hyun Sook(백현숙)
Son, Hyun Joo(손현주)
Woo, Yeon I.(우연이)
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
Han, Dong Wook(한동욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95926
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