2 158

Cited 17 times in

Effects of surface morphology on human osteosarcoma cell response

Authors
 B.H. Zhao  ;  I.-S. Lee  ;  S.-M. Chung  ;  J.-C. Park  ;  I.H. Han 
Citation
 CURRENT APPLIED PHYSICS, Vol.7(s1) : 6-10, 2007 
Journal Title
 CURRENT APPLIED PHYSICS 
ISSN
 1567-1739 
Issue Date
2007
Abstract
It is known that surface roughness enhances the anchorage of implants to bone and opens up the possibilities of the incorporation and release of antibiotics around titanium implants. In this study, titanium oxide was formed by the micro-arc oxidation (MAO) method. Commercially available pure titanium disks with diameter of 10 mm and 2 mm in thickness were used as substrates. MAO of the specimen was carried out in an aqueous electrolyte by applying a pulsed DC wave to the specimen. The surface characteristics of the MAO implants, including surface morphology and surface roughness, were analyzed by SEM and surface profilometer, respectively. The purpose of this study is to evaluate the effect produced by MAO of the titanium surface on cell cultures by cell proliferation assay, cell morphology and alkaline phosphatase activity. The results showed the formation of an oxide layer with micropores and roughness by MAO. No significant difference in the proliferation and spreading morphology of machined, blasted and MAO surfaces was observed. However, the ALP activity of osteoblast cells on MAO surface was higher than on machined and blasted surfaces in 4 day and 7 day cultures, respectively. From this study, it was concluded that the MAO-treated titanium exhibited an effect on early osteoblast differentiation.
Full Text
http://www.sciencedirect.com/science/article/pii/S1567173906002136
DOI
10.1016/j.cap.2006.11.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95925
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse