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당뇨병 고위험군 및 내당능장애자에서 Mosapride, 5HT-4 Agonist의 2주간 투여가 인슐린 감수성에 미치는 영향

Other Titles
 The Effect of Mosapride, 5HT-4 Agonist on Insulin Sensitivity of Patients with IGT and High Risk Group of Type 2 Diabetes Mellitus 
 남주영  ;  조민호  ;  이현철  ;  김경래  ;  임승길  ;  송영득  ;  차봉수  ;  안철우  ;  강은석  ;  박종숙  ;  김혜진  ;  남지선  ;  윤지은  ;  정한영 
 Clinical Diabetes (임상당뇨병), Vol.8(1) : 74-80, 2007 
Journal Title
 Clinical Diabetes (임상당뇨병) 
Issue Date
Introduction: Mosapride, a benzamide derivative, is widely used in patients with motility disorders as a prokinetic agent. Recent studies suggested that mosapride may modulate the secretion and/or action of insulin through 5HT receptors. So we investigated the potential effect of mosapride on insulin sensitivity in subjects with impaired glucose tolerance, having high risks for Type 2 diabetes mellitus. Methods: Thirty subjects were selected for this study with informed consent (20:mosapride group, 10: placebo control group). Insulin sensitivity was measured by euglycemic Hyperinsulinemic clamp, before and after two weeks of mosapride administration. Results: No difference was found between the two groups in terms of sex, age, BMI, blood pressure, total cholesterol, triglyceride and HDL-cholesterol. After 2 weeks treatment of mosapride, fasting plasma glucose levels and insulin levels were decreased. Follow-up glucose disposal rates were higher than the Initial values, and were comparable to those of control subjects. Conclusion: Mosapride improved insulin action in pre-diabetic subjects and it can be regarded as a supplementary insulin sensitizer.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Kim, Hae Jin(김혜진)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cho, Min Ho(조민호)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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