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당뇨병 고위험군 및 내당능장애자에서 Mosapride, 5HT-4 Agonist의 2주간 투여가 인슐린 감수성에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 김경래 | - |
dc.contributor.author | 김혜진 | - |
dc.contributor.author | 남지선 | - |
dc.contributor.author | 박종숙 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 조민호 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2014-12-21T16:32:16Z | - |
dc.date.available | 2014-12-21T16:32:16Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1229-9693 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95877 | - |
dc.description.abstract | Introduction: Mosapride, a benzamide derivative, is widely used in patients with motility disorders as a prokinetic agent. Recent studies suggested that mosapride may modulate the secretion and/or action of insulin through 5HT receptors. So we investigated the potential effect of mosapride on insulin sensitivity in subjects with impaired glucose tolerance, having high risks for Type 2 diabetes mellitus. Methods: Thirty subjects were selected for this study with informed consent (20:mosapride group, 10: placebo control group). Insulin sensitivity was measured by euglycemic Hyperinsulinemic clamp, before and after two weeks of mosapride administration. Results: No difference was found between the two groups in terms of sex, age, BMI, blood pressure, total cholesterol, triglyceride and HDL-cholesterol. After 2 weeks treatment of mosapride, fasting plasma glucose levels and insulin levels were decreased. Follow-up glucose disposal rates were higher than the Initial values, and were comparable to those of control subjects. Conclusion: Mosapride improved insulin action in pre-diabetic subjects and it can be regarded as a supplementary insulin sensitizer. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | Clinical Diabetes (임상당뇨병) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 당뇨병 고위험군 및 내당능장애자에서 Mosapride, 5HT-4 Agonist의 2주간 투여가 인슐린 감수성에 미치는 영향 | - |
dc.title.alternative | The Effect of Mosapride, 5HT-4 Agonist on Insulin Sensitivity of Patients with IGT and High Risk Group of Type 2 Diabetes Mellitus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 남주영 | - |
dc.contributor.googleauthor | 조민호 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.googleauthor | 송영득 | - |
dc.contributor.googleauthor | 차봉수 | - |
dc.contributor.googleauthor | 안철우 | - |
dc.contributor.googleauthor | 강은석 | - |
dc.contributor.googleauthor | 박종숙 | - |
dc.contributor.googleauthor | 김혜진 | - |
dc.contributor.googleauthor | 남지선 | - |
dc.contributor.googleauthor | 윤지은 | - |
dc.contributor.googleauthor | 정한영 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00294 | - |
dc.contributor.localId | A01179 | - |
dc.contributor.localId | A01268 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A03819 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A01660 | - |
dc.relation.journalcode | J00568 | - |
dc.identifier.url | http://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=2616733 | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Kyung Rae | - |
dc.contributor.alternativeName | Kim, Hae Jin | - |
dc.contributor.alternativeName | Nam, Ji Sun | - |
dc.contributor.alternativeName | Park, Jong Suk | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Cho, Min Ho | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Rae | - |
dc.contributor.affiliatedAuthor | Kim, Hae Jin | - |
dc.contributor.affiliatedAuthor | Nam, Ji Sun | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Cho, Min Ho | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Park, Jong Suk | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 74 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | Clinical Diabetes (임상당뇨병), Vol.8(1) : 74-80, 2007 | - |
dc.identifier.rimsid | 53261 | - |
dc.type.rims | ART | - |
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