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Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit

Authors
 Su Bun Jeon  ;  Gutae Kim  ;  In Kyeom Kim  ;  Young-Ho Lee  ;  Heung-Mook Shin  ;  Kyoungho Suk  ;  Sang-Hyun Kim  ;  Young Mi Seok  ;  Jee In Kim 
Citation
 CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Vol.34(11) : 1116-1120, 2007 
Journal Title
 CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 
ISSN
 0305-1870 
Issue Date
2007
Abstract
1. Flavonoids modulate vascular tone through an endothelium-dependent or -independent mechanism. Although a few mechanisms for endothelium-independent relaxation have been suggested, such as interference with protein kinase C or cAMP or cGMP phosphodiesterase, the inhibition of Ca(2+) release from intracellular stores or Ca(2+) influx from extracellular fluids, the mode of action of flavonoids remains elusive. 2. We hypothesized that treatment with flavone inhibits vascular smooth muscle contraction by decreasing the phosphorylation of the myosin phosphatase target subunit (MYPT1). 3. Rat aortic rings were denuded of endothelium, mounted in organ baths and contracted with U46619, a thromboxane A(2) analogue. 4. Flavone dose-dependently inhibited the U46619-induced contractile response and myosin light chain (MLC(20)) phosphorylation. At 10(-7) mol/L, U46619 induced vascular contraction with the concomitant phosphorylation of MYPT1 at Thr855, but not at Thr697. Incubation with flavone (100 or 300 micromol/L) for 30 min attenuated the phosphorylation of MYPT1(Thr855), but not MYPT1(Thr697). 5. It is concluded that treatment with flavone inhibits vascular smooth muscle contraction by decreasing the phosphorylation of the MYPT1. These results suggest that flavone causes endothelium-independent relaxation through, at least in part, the inhibition of p160 Rho-associated coiled-coil-containing protein kinase (ROCK) signalling.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1681.2007.04672.x/abstract
DOI
10.1111/j.1440-1681.2007.04672.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Young Ho(이영호) ORCID logo https://orcid.org/0000-0002-5749-1045
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95870
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