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Flavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit

DC FieldValueLanguage
dc.contributor.author이영호-
dc.date.accessioned2014-12-21T16:32:03Z-
dc.date.available2014-12-21T16:32:03Z-
dc.date.issued2007-
dc.identifier.issn0305-1870-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95870-
dc.description.abstract1. Flavonoids modulate vascular tone through an endothelium-dependent or -independent mechanism. Although a few mechanisms for endothelium-independent relaxation have been suggested, such as interference with protein kinase C or cAMP or cGMP phosphodiesterase, the inhibition of Ca(2+) release from intracellular stores or Ca(2+) influx from extracellular fluids, the mode of action of flavonoids remains elusive. 2. We hypothesized that treatment with flavone inhibits vascular smooth muscle contraction by decreasing the phosphorylation of the myosin phosphatase target subunit (MYPT1). 3. Rat aortic rings were denuded of endothelium, mounted in organ baths and contracted with U46619, a thromboxane A(2) analogue. 4. Flavone dose-dependently inhibited the U46619-induced contractile response and myosin light chain (MLC(20)) phosphorylation. At 10(-7) mol/L, U46619 induced vascular contraction with the concomitant phosphorylation of MYPT1 at Thr855, but not at Thr697. Incubation with flavone (100 or 300 micromol/L) for 30 min attenuated the phosphorylation of MYPT1(Thr855), but not MYPT1(Thr697). 5. It is concluded that treatment with flavone inhibits vascular smooth muscle contraction by decreasing the phosphorylation of the MYPT1. These results suggest that flavone causes endothelium-independent relaxation through, at least in part, the inhibition of p160 Rho-associated coiled-coil-containing protein kinase (ROCK) signalling.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1116~1120-
dc.relation.isPartOfCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleFlavone inhibits vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학)-
dc.contributor.googleauthorSu Bun Jeon-
dc.contributor.googleauthorGutae Kim-
dc.contributor.googleauthorIn Kyeom Kim-
dc.contributor.googleauthorYoung-Ho Lee-
dc.contributor.googleauthorHeung-Mook Shin-
dc.contributor.googleauthorKyoungho Suk-
dc.contributor.googleauthorSang-Hyun Kim-
dc.contributor.googleauthorYoung Mi Seok-
dc.contributor.googleauthorJee In Kim-
dc.identifier.doi10.1111/j.1440-1681.2007.04672.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02968-
dc.relation.journalcodeJ00553-
dc.identifier.eissn1437-7799-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1440-1681.2007.04672.x/abstract-
dc.contributor.alternativeNameLee, Young Ho-
dc.contributor.affiliatedAuthorLee, Young Ho-
dc.rights.accessRightsnot free-
dc.citation.volume34-
dc.citation.number11-
dc.citation.startPage1116-
dc.citation.endPage1120-
dc.identifier.bibliographicCitationCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Vol.34(11) : 1116-1120, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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