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Lipoprotein(a) and LDL Particle Size Are Related to the Severity of Coronary Artery Disease

 Jae-Youn Moon  ;  Hyuck Moon Kwon  ;  Hyun Seung Kim  ;  Se-Joong Rim  ;  Bum-Kee Hong  ;  Young Won Yoon  ;  Ji-Hyuck Rhee  ;  Jong Kwan Park  ;  Sung-Ju Lee  ;  Jung-Sun Kim  ;  Se-Jung Yoon  ;  Sung Woo Kwon 
 CARDIOLOGY, Vol.108(4) : 282-289, 2007 
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BACKGROUND: The pathophysiological role and metabolic pathway of Lp(a) have not been clearly defined. An association between Lp(a) and oxidative low-density lipoprotein (LDL) were recently reported. And small dense LDL (sd-LDL) were associated with circulating malondialdehyde-modified LDL. We investigated the relationships between serum Lp(a) level and LDL particle size in coronary artery disease (CAD) patients. Further, we investigated the relationships of sd-LDL and Lp(a) with the extent and severity of CAD. METHODS: A total of 490 patients (mean: 60.5 +/- 11.5 years old) who underwent coronary angiography to evaluate chest pain were investigated. Patients were classified into two groups, a CAD group (n = 256), who had significant stenosis observed by coronary angiogram, and a control group (n = 234), who had normal, or minimal coronary arteries. CAD severity was measured by Gensini scores. The distribution of the LDL subfraction was analyzed using a Quantimetrix Lipoprint LDL System. RESULTS: The serum Lp(a) concentration was correlated with the fraction of sd-LDL (r = 0.193, p < 0.001) and mean LDL size (r = 0.160, p = 0.003). The Lp(a) level and mean LDL particle size were significantly correlated with a high Gensini score. LDL particle size in the CAD group was smaller than in the control group (26.74 +/- 0.64 vs. 26.43 +/- 0.93 nm, p < 0.001). The Gensini score was significantly higher in small LDL with high Lp(a) level groups. CONCLUSION: The positive correlation of the level of Lp(a) and sd-LDL fraction were demonstrated. The mechanism of this association is not clearly defined; we can suggest that it may stem from the individual atherogenic condition that linked to increased oxidative stress. Both increased Lp(a) and sd-LDL fraction were correlated with the severity of CAD.
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1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Kim, Hyun Seung(김현승)
Yoon, Se Jung(윤세정)
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Rhee, Ji Hyuk(이지혁)
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
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