Cited 42 times in
Lipoprotein(a) and LDL Particle Size Are Related to the Severity of Coronary Artery Disease
DC Field | Value | Language |
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dc.contributor.author | 권혁문 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 김현승 | - |
dc.contributor.author | 윤세정 | - |
dc.contributor.author | 윤영원 | - |
dc.contributor.author | 이지혁 | - |
dc.contributor.author | 임세중 | - |
dc.contributor.author | 홍범기 | - |
dc.date.accessioned | 2014-12-21T16:29:47Z | - |
dc.date.available | 2014-12-21T16:29:47Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0008-6312 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95801 | - |
dc.description.abstract | BACKGROUND: The pathophysiological role and metabolic pathway of Lp(a) have not been clearly defined. An association between Lp(a) and oxidative low-density lipoprotein (LDL) were recently reported. And small dense LDL (sd-LDL) were associated with circulating malondialdehyde-modified LDL. We investigated the relationships between serum Lp(a) level and LDL particle size in coronary artery disease (CAD) patients. Further, we investigated the relationships of sd-LDL and Lp(a) with the extent and severity of CAD. METHODS: A total of 490 patients (mean: 60.5 +/- 11.5 years old) who underwent coronary angiography to evaluate chest pain were investigated. Patients were classified into two groups, a CAD group (n = 256), who had significant stenosis observed by coronary angiogram, and a control group (n = 234), who had normal, or minimal coronary arteries. CAD severity was measured by Gensini scores. The distribution of the LDL subfraction was analyzed using a Quantimetrix Lipoprint LDL System. RESULTS: The serum Lp(a) concentration was correlated with the fraction of sd-LDL (r = 0.193, p < 0.001) and mean LDL size (r = 0.160, p = 0.003). The Lp(a) level and mean LDL particle size were significantly correlated with a high Gensini score. LDL particle size in the CAD group was smaller than in the control group (26.74 +/- 0.64 vs. 26.43 +/- 0.93 nm, p < 0.001). The Gensini score was significantly higher in small LDL with high Lp(a) level groups. CONCLUSION: The positive correlation of the level of Lp(a) and sd-LDL fraction were demonstrated. The mechanism of this association is not clearly defined; we can suggest that it may stem from the individual atherogenic condition that linked to increased oxidative stress. Both increased Lp(a) and sd-LDL fraction were correlated with the severity of CAD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 282~289 | - |
dc.relation.isPartOf | CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Lipoprotein(a) and LDL Particle Size Are Related to the Severity of Coronary Artery Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jae-Youn Moon | - |
dc.contributor.googleauthor | Hyuck Moon Kwon | - |
dc.contributor.googleauthor | Hyun Seung Kim | - |
dc.contributor.googleauthor | Se-Joong Rim | - |
dc.contributor.googleauthor | Bum-Kee Hong | - |
dc.contributor.googleauthor | Young Won Yoon | - |
dc.contributor.googleauthor | Ji-Hyuck Rhee | - |
dc.contributor.googleauthor | Jong Kwan Park | - |
dc.contributor.googleauthor | Sung-Ju Lee | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Se-Jung Yoon | - |
dc.contributor.googleauthor | Sung Woo Kwon | - |
dc.identifier.doi | 10.1159/000099097 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00260 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A01120 | - |
dc.contributor.localId | A02569 | - |
dc.contributor.localId | A02580 | - |
dc.contributor.localId | A03213 | - |
dc.contributor.localId | A03372 | - |
dc.contributor.localId | A04394 | - |
dc.relation.journalcode | J00457 | - |
dc.identifier.eissn | 1421-9751 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/99097 | - |
dc.contributor.alternativeName | Kwon, Hyuck Moon | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Kim, Hyun Seung | - |
dc.contributor.alternativeName | Yoon, Se Jung | - |
dc.contributor.alternativeName | Yoon, Young Won | - |
dc.contributor.alternativeName | Rhee, Ji Hyuk | - |
dc.contributor.alternativeName | Rim, Se Joong | - |
dc.contributor.alternativeName | Hong, Bum Kee | - |
dc.contributor.affiliatedAuthor | Kwon, Hyuck Moon | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Seung | - |
dc.contributor.affiliatedAuthor | Yoon, Se Jung | - |
dc.contributor.affiliatedAuthor | Yoon, Young Won | - |
dc.contributor.affiliatedAuthor | Rhee, Ji Hyuk | - |
dc.contributor.affiliatedAuthor | Rim, Se Joong | - |
dc.contributor.affiliatedAuthor | Hong, Bum Kee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 108 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 282 | - |
dc.citation.endPage | 289 | - |
dc.identifier.bibliographicCitation | CARDIOLOGY, Vol.108(4) : 282-289, 2007 | - |
dc.identifier.rimsid | 51550 | - |
dc.type.rims | ART | - |
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