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A der(1;15)(q10;q10) is a rare nonrandom whole-arm translocation in patients with acute lymphoblastic leukemia

Authors
 Tae Sung Park  ;  Jaewoo Song  ;  Jong Rak Choi  ;  Chuhl Joo Lyu  ;  Jin Seok Kim  ;  Seoyoung Yoon  ;  Sang-Guk Lee  ;  Kyung-A. Lee 
Citation
 CANCER GENETICS AND CYTOGENETICS , Vol.179(2) : 132-135, 2007 
Journal Title
 CANCER GENETICS AND CYTOGENETICS 
ISSN
 0165-4608 
Issue Date
2007
Abstract
A rare karyotypic event, der(1;15)(q10;q10), which involves the whole long arms of chromosomes 1 and 15, has been reported in patients with various conditions, including acute myelogenous leukemia, myelodysplastic syndrome, polycythemia vera, and multiple myeloma. Only 27 cases of unbalanced der(1;15)(q10;q10) have been documented in the literature as single or complexed chromosomal abnormalities in hematological malignancies. Here, we describe two cases of acute lymphoblastic leukemia with der(1;15)(q10;q10), and review the previous reports. Although more case studies are needed, we suggest that der(1;15)(q10;q10) should be considered a nonrandom chromosomal abnormality in hematological malignancies including both lymphoid and myeloid neoplasms.
Full Text
http://www.sciencedirect.com/science/article/pii/S0165460807005006
DOI
10.1016/j.cancergencyto.2007.08.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Park, Tae Sung(박태성)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95784
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