Cited 23 times in
Phase II trial of irinotecan and cisplatin with early concurrent radiotherapy in limited-disease small-cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | 문용화 | - |
dc.contributor.author | 손주혁 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정경영 | - |
dc.contributor.author | 최병욱 | - |
dc.contributor.author | 최혜진 | - |
dc.contributor.author | 김귀언 | - |
dc.contributor.author | 김세규 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 김주항 | - |
dc.date.accessioned | 2014-12-21T16:28:55Z | - |
dc.date.available | 2014-12-21T16:28:55Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0008-543X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95774 | - |
dc.description.abstract | BACKGROUND: A Phase II trial of irinotecan and cisplatin (IP) with early concurrent radiotherapy was performed in limited-disease small-cell lung cancer (LD-SCLC) to evaluate the efficacy and toxicity. METHODS: For untreated LD-SCLC patients, irinotecan (60 mg/m2, Days 1, 8, and 15) and cisplatin (40 mg/m2, Days 1 and 8) were repeated every 4 weeks for a maximum of 6 cycles. Thoracic radiotherapy of 1.8 Gy/day was begun on Day 1 of the second chemotherapy cycle, up to a total of 45 to 54 Gy. Prophylactic cranial irradiation (30 Gy in 10 fractions) was performed on patients with a complete response (CR). RESULTS: Thirty-three LD-SCLC patients were enrolled. The median age was 60 years and 31 patients had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1. Twelve (36.4%) patients had N3 disease. The response rate was 87.9%, with a CR rate of 45.5%. At a median follow-up period of 27 months the median progression-free survival (PFS) and overall survival (OS) were 14.4 and 26.1 months, respectively, with 2-year PFS and OS rates of 26.8% and 54.9%. The dominating toxicity was neutropenia, with grade 3-5 of 81.8%. The most common grade 3-5 nonhematologic toxicities were diarrhea (21.2%), anorexia (21.2%), and fatigue (21.2%). Grade 3-5 radiation esophagitis and pneumonitis occurred in 18.2% and 9.1% of patients, respectively. There were 2 treatment-related deaths from sepsis and radiation pneumonitis. CONCLUSIONS: IP with early concurrent radiotherapy was effective and tolerable in untreated LD-SCLC. Copyright (c) 2007 American Cancer Society | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1845~1850 | - |
dc.relation.isPartOf | CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Phase II trial of irinotecan and cisplatin with early concurrent radiotherapy in limited-disease small-cell lung cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Joo Hyuk Sohn | - |
dc.contributor.googleauthor | Yong Wha Moon | - |
dc.contributor.googleauthor | Joo-Hang Kim | - |
dc.contributor.googleauthor | Hye Jin Choi | - |
dc.contributor.googleauthor | Byoung Wook Choi | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Se Kyu Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.contributor.googleauthor | Gwi Eon Kim | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.identifier.doi | 10.1002/cncr.22621 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01370 | - |
dc.contributor.localId | A01995 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03571 | - |
dc.contributor.localId | A04059 | - |
dc.contributor.localId | A04219 | - |
dc.contributor.localId | A00321 | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A00945 | - |
dc.relation.journalcode | J00434 | - |
dc.identifier.eissn | 1097-0142 | - |
dc.contributor.alternativeName | Moon, Yong Wha | - |
dc.contributor.alternativeName | Sohn, Joo Hyuk | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.contributor.alternativeName | Choi, Byoung Wook | - |
dc.contributor.alternativeName | Choi, Hye Jin | - |
dc.contributor.alternativeName | Kim, Gwi Eon | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Moon, Yong Wha | - |
dc.contributor.affiliatedAuthor | Sohn, Joo Hyuk | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Chung, Kyung Young | - |
dc.contributor.affiliatedAuthor | Choi, Byoung Wook | - |
dc.contributor.affiliatedAuthor | Choi, Hye Jin | - |
dc.contributor.affiliatedAuthor | Kim, Gwi Eon | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 109 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1845 | - |
dc.citation.endPage | 1850 | - |
dc.identifier.bibliographicCitation | CANCER, Vol.109(9) : 1845-1850, 2007 | - |
dc.identifier.rimsid | 51539 | - |
dc.type.rims | ART | - |
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