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Intramuscular immunoglobulin for recalcitrant suppurative diseases of the skin: A retrospective review of 63 cases

Authors
 B. Goo  ;  H.J. Chung  ;  K.Y. Chung  ;  W.G. Chung 
Citation
 BRITISH JOURNAL OF DERMATOLOGY, Vol.157(3) : 563-568, 2007 
Journal Title
 BRITISH JOURNAL OF DERMATOLOGY 
ISSN
 0007-0963 
Issue Date
2007
Abstract
BACKGROUND: Intramuscular human immunoglobulin (HIG) may provide a therapeutic option as an independent or combined treatment for recalcitrant suppurative skin diseases such as hidradenitis suppurativa, folliculitis decalvans, or chronic recurrent furunculosis or folliculitis. OBJECTIVES: To define the efficacy and safety of intramuscular HIG for chronic and recalcitrant suppurative skin diseases. METHODS: Patients who had received HIG for hidradenitis suppurativa, folliculitis decalvans, furunculosis or folliculitis at Severance Hospital, Seoul, Korea, between January 2000 and May 2005 were identified from medical/pharmacy records. All records were analysed retrospectively. RESULTS: Sixty-three patients were identified. After treatment, 37 patients (59%) showed overall improvement and were rated as having an 'excellent response' or 'good response' by the attending physician. No improvement or worsening was seen in only three patients (5%). A period without new lesions (PWNL) was achieved in 46 patients (73%). The number of times HIG was administered to achieve PWNL ranged from 1 to 12 (mean +/- SD 2.15 +/- 1.69). There was no significant difference in the rating score between the independent intramuscular HIG and the combined treatment groups. Pain at the injection site was the major side-effect, which led to the discontinuation of treatment in five patients. No other significant systemic side-effects were observed. CONCLUSIONS: Our results demonstrate that intramuscular HIG may be used for the treatment of recalcitrant suppurative skin diseases as an independent or combined treatment.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2007.08069.x/abstract
DOI
10.1111/j.1365-2133.2007.08069.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
Chung, Woo Gil(정우길)
Chung, Hye Jin(정혜진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95756
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