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Larger numbers of immature dendritic cells augment an anti-tumor effect against established murine melanoma cells

Authors
 Tae-Hyung Lee  ;  Young-Hun Cho  ;  Min-Geol Lee 
Citation
 BIOTECHNOLOGY LETTERS, Vol.29(3) : 351-357, 2007 
Journal Title
 BIOTECHNOLOGY LETTERS 
ISSN
 0141-5492 
Issue Date
2007
Abstract
The dendritic cell (DC) is a potentially promising tool for cancer immunotherapy. To date, however, DC-based immunotherapy has not yielded data with which firm conclusions can be drawn. In the present study, we tested the dose-dependant enhancement of the anti-tumor effect induced by DCs. When large numbers of DCs were used, tumor growth was suppressed up to 41% when compared to control mice. Survival of the animals was prolonged to 54 days compared to the 33-day survival the control mice. The delayed-type hypersensitivity (DTH) response induced was 26-fold higher than in the controls. Larger numbers of DCs also led to higher expansion of IFN-γ-secreting-CD8+ T cells. Furthermore, the secretion of IL-12p70 and IFN-γ by spleen cells were enhanced in proportion to the dosage. However, the level of IL-4 secreted from spleen cells was negligible compared to the level of IFN-γ that was released. These results indicate that DCs induce Th1-dominant immune response and that more DCs could lead to better immunological results, a finding which was consistent with our therapeutic results.
Full Text
http://link.springer.com/article/10.1007%2Fs10529-006-9260-y
DOI
10.1007/s10529-006-9260-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Cho, Young Hun(조영훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95726
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