Cited 16 times in
Larger numbers of immature dendritic cells augment an anti-tumor effect against established murine melanoma cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이민걸 | - |
dc.contributor.author | 조영훈 | - |
dc.date.accessioned | 2014-12-21T16:27:22Z | - |
dc.date.available | 2014-12-21T16:27:22Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95726 | - |
dc.description.abstract | The dendritic cell (DC) is a potentially promising tool for cancer immunotherapy. To date, however, DC-based immunotherapy has not yielded data with which firm conclusions can be drawn. In the present study, we tested the dose-dependant enhancement of the anti-tumor effect induced by DCs. When large numbers of DCs were used, tumor growth was suppressed up to 41% when compared to control mice. Survival of the animals was prolonged to 54 days compared to the 33-day survival the control mice. The delayed-type hypersensitivity (DTH) response induced was 26-fold higher than in the controls. Larger numbers of DCs also led to higher expansion of IFN-γ-secreting-CD8+ T cells. Furthermore, the secretion of IL-12p70 and IFN-γ by spleen cells were enhanced in proportion to the dosage. However, the level of IL-4 secreted from spleen cells was negligible compared to the level of IFN-γ that was released. These results indicate that DCs induce Th1-dominant immune response and that more DCs could lead to better immunological results, a finding which was consistent with our therapeutic results. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 351~357 | - |
dc.relation.isPartOf | BIOTECHNOLOGY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Larger numbers of immature dendritic cells augment an anti-tumor effect against established murine melanoma cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Tae-Hyung Lee | - |
dc.contributor.googleauthor | Young-Hun Cho | - |
dc.contributor.googleauthor | Min-Geol Lee | - |
dc.identifier.doi | 10.1007/s10529-006-9260-y | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02779 | - |
dc.contributor.localId | A03861 | - |
dc.relation.journalcode | J00336 | - |
dc.identifier.eissn | 1573-6776 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10529-006-9260-y | - |
dc.contributor.alternativeName | Lee, Min Geol | - |
dc.contributor.alternativeName | Cho, Young Hun | - |
dc.contributor.affiliatedAuthor | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Cho, Young Hun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 351 | - |
dc.citation.endPage | 357 | - |
dc.identifier.bibliographicCitation | BIOTECHNOLOGY LETTERS, Vol.29(3) : 351-357, 2007 | - |
dc.identifier.rimsid | 51512 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.