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Transcriptional activation of SHP by PPAR-γ in liver

Authors
 Ha-il Kim  ;  Yoo-Kyung Koh  ;  Tae-Hyun Kim  ;  Sool-Ki Kwon  ;  Seung-Soon Im  ;  Hueng-Sik Choi  ;  Kyung-Sup Kim  ;  Yong-Ho Ahn 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.360(2) : 301-306, 2007 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2007
Abstract
The mechanism of how PPARγ decrease gluconeogenic gene expressions in liver is still unclear. Since PPARγ is a transcriptional activator, it requires a mediator to decrease the transcription of gluconeogenic genes. Recently, SHP has been shown to mediate the bile acid-dependent down regulation of gluconeogenic gene expression in liver. This led us to explore the possibility that SHP may mediate the antigluconeogenic effect of PPARγ. In the present study, we have identified and characterized the presence of functional PPRE in human SHP promoter. We show the binding of PPARγ/RXRα heterodimer to the PPRE and increased SHP expression by rosiglitazone in primary rat hepatocytes. Taken together with the previous reports about the function of SHP on gluconeogenesis, our results indicate that SHP can mediate the acute antigluconeogenic effect of PPARγ.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X07010984
DOI
10.1016/j.bbrc.2007.05.171
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Koh, Yoo Kyung(고유경)
Kwon, Sool Ki(권슬기)
Kim, Kyung Sup(김경섭) ORCID logo https://orcid.org/0000-0001-8483-8537
Kim, Tae Hyun(김태현)
Kim, Ha Il(김하일)
Ahn, Yong Ho(안용호) ORCID logo https://orcid.org/0000-0002-4133-0757
Im, Seung Soon(임승순)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95695
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